6-(4-(phenyl)piperazine-1-yl)-3(2H)-pyridazinone-2-ylacetohydrazide

Base Information

• Chemical Name: 6-(4-(phenyl)piperazine-1-yl)-3(2H)-pyridazinone-2-ylacetohydrazide
• CAS No.: 1312719-50-8
• Molecular Formula: C₁₆H₂₀N₆O₂
• Molecular Weight: 328.374
• Mol file: 1312719-50-8.mol

Synonyms:6-(4-(phenyl)piperazine-1-yl)-3(2H)-pyridazinone-2-ylacetohydrazide

Chemical Property of 6-(4-(phenyl)piperazine-1-yl)-3(2H)-pyridazinone-2-ylacetohydrazide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-(4-(phenyl)piperazine-1-yl)-3(2H)-pyridazinone-2-ylacetohydrazide

There total 4 articles about 6-(4-(phenyl)piperazine-1-yl)-3(2H)-pyridazinone-2-ylacetohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

ethyl 6-(4-(phenyl)piperazine-1-yl)-3(2H)-pyridazinone-2-ylacetate (931364-92-0) → 6-(4-(phenyl)piperazine-1-yl)-3(2H)-pyridazinone-2-ylacetohydrazide (1312719-50-8)

Guidance literature:

With hydrazine hydrate; In methanol; at 20 ℃; for 3h;

DOI:10.1007/s43440-020-00070-w

Reference yield:

4-phenyl-1-piperazine (92-54-6) → 6-(4-(phenyl)piperazine-1-yl)-3(2H)-pyridazinone-2-ylacetohydrazide (1312719-50-8)

Guidance literature:

Multi-step reaction with 4 steps

1: ethanol / 6 h / Reflux

2: acetic acid / 6 h / Reflux

3: potassium carbonate / acetone / Reflux

4: hydrazine hydrate / methanol / 3 h / 20 °C

With potassium carbonate; hydrazine hydrate; acetic acid; In methanol; ethanol; acetone;

DOI:10.2174/1570178614666170707154210

Reference yield:

3-chloro-6-(4-phenylpiperazin-1-yl)pyridazine (100240-53-7) → 6-(4-(phenyl)piperazine-1-yl)-3(2H)-pyridazinone-2-ylacetohydrazide (1312719-50-8)

Guidance literature:

Multi-step reaction with 3 steps

1: acetic acid / 6 h / Reflux

2: potassium carbonate / acetone / Reflux

3: hydrazine hydrate / methanol / 3 h / 20 °C

With potassium carbonate; hydrazine hydrate; acetic acid; In methanol; acetone;

DOI:10.2174/1570178614666170707154210

upstream raw materials:

ethyl 6-(4-(phenyl)piperazine-1-yl)-3(2H)-pyridazinone-2-ylacetate

4-phenyl-1-piperazine

3-chloro-6-(4-phenylpiperazin-1-yl)pyridazine

6-(4-(phenyl)piperazine-1-yl)-3(2H)-pyridazinone

Downstream raw materials:

C₂₄H₂₅FN₆O₂

C₂₄H₂₅ClN₆O₂

C₂₄H₂₅BrN₆O₂

C₂₄H₂₆N₆O₂