3-Chloro-6-(4-phenylpiperazin-1-yl)pyridazine

Base Information

• Chemical Name: 3-Chloro-6-(4-phenylpiperazin-1-yl)pyridazine
• CAS No.: 100240-53-7
• Molecular Formula: C14H15ClN4
• Molecular Weight: 274.75
• Mol file: 100240-53-7.mol

Synonyms:

Chemical Property of 3-Chloro-6-(4-phenylpiperazin-1-yl)pyridazine

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

3-Chloro-6-(4-phenylpiperazin-1-yl)pyridazine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-Chloro-6-(4-phenylpiperazin-1-yl)pyridazine

There total 1 articles about 3-Chloro-6-(4-phenylpiperazin-1-yl)pyridazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

3,6-dichlorpyridazine (141-30-0) + 4-phenyl-1-piperazine (92-54-6) → 3-chloro-6-(4-phenylpiperazin-1-yl)pyridazine (100240-53-7)

Guidance literature:

With triethylamine; In N,N-dimethyl-formamide; at 80 ℃;

DOI:10.1021/jo3022428

Reference yield:

3-chloro-6-(4-phenylpiperazin-1-yl)pyridazine (100240-53-7) → 6-(4-(phenyl)piperazine-1-yl)-3(2H)-pyridazinone-2-ylacetohydrazide (1312719-50-8)

Guidance literature:

Multi-step reaction with 3 steps

1: acetic acid / 6 h / Reflux

2: potassium carbonate / acetone / Reflux

3: hydrazine hydrate / methanol / 3 h / 20 °C

With potassium carbonate; hydrazine hydrate; acetic acid; In methanol; acetone;

DOI:10.2174/1570178614666170707154210

Reference yield:

3-chloro-6-(4-phenylpiperazin-1-yl)pyridazine (100240-53-7) → C19H24N4O3 (1254944-53-0)

Guidance literature:

Multi-step reaction with 2 steps

1: water; sodium acetate; acetic acid / Reflux

2: potassium carbonate / acetone / Reflux

With water; sodium acetate; potassium carbonate; acetic acid; In acetone;

upstream raw materials:

3,6-dichlorpyridazine

4-phenyl-1-piperazine

Downstream raw materials:

C₁₉H₂₄N₄O₃

C₁₇H₂₂N₆O₂

6-(4-(phenyl)piperazine-1-yl)-3(2H)-pyridazinone-2-ylacetohydrazide

Refernces

• 1、 ?iftci, Osman,?zdemir, Zeynep,Acar, Ceren,S?zen, Mert,Ba?ak-Türkmen, Ne?e,Ayhan, ?dris,G?zükara, Harika. "The novel synthesized pyridazinone derivates had the antiproliferative and apoptotic effects in SHSY5Y and HEP3B cancer cell line". . p. 323 - 331. Retrieved 2018/04/20.
• 2、 Sengmany, Stephane,Vitu-Thiebaud, Arnaud,Le Gall, Erwan,Condon, Sylvie,Leonel, Eric,Thobie-Gautier, Christine,Pipelier, Muriel,Lebreton, Jacques,Dubreuil, Didier. "An electrochemical nickel-catalyzed arylation of 3-amino-6- chloropyridazines". . p. 370 - 379. Retrieved 2013/03/13.