α-diethoxyphosphoryl-α-benzyl-γ-phenyl-γ-butyrolactone

Base Information

• Chemical Name: α-diethoxyphosphoryl-α-benzyl-γ-phenyl-γ-butyrolactone
• CAS No.: 1008789-05-6
• Molecular Formula: C₂₁H₂₅O₅P
• Molecular Weight: 388.4
• Mol file: 1008789-05-6.mol

Synonyms:α-diethoxyphosphoryl-α-benzyl-γ-phenyl-γ-butyrolactone

Chemical Property of α-diethoxyphosphoryl-α-benzyl-γ-phenyl-γ-butyrolactone

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of α-diethoxyphosphoryl-α-benzyl-γ-phenyl-γ-butyrolactone

There total 1 articles about α-diethoxyphosphoryl-α-benzyl-γ-phenyl-γ-butyrolactone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

(2-oxo-5-phenyltetrahydrofuran-3-yl)-phosphonic acid diethyl ester (1008788-92-8) + benzyl bromide (100-39-0) → α-diethoxyphosphoryl-α-benzyl-γ-phenyl-γ-butyrolactone (1008789-05-6)

Guidance literature:

(2-oxo-5-phenyltetrahydrofuran-3-yl)-phosphonic acid diethyl ester; With lithium diisopropyl amide; In tetrahydrofuran; at 0 ℃; for 0.25h;

benzyl bromide; In tetrahydrofuran; at -70 - 20 ℃; for 21h; Further stages.;

DOI:10.1039/b712145h

Reference yield: 80.0%

α-diethoxyphosphoryl-α-benzyl-γ-phenyl-γ-butyrolactone (1008789-05-6) + ethanol (64-17-5) → 1-benzyl-2-phenylcyclopropanecarboxylic acid ethyl ester

Guidance literature:

With sodium hydride; In tetrahydrofuran; for 8h; Heating;

DOI:10.1039/b712145h

Reference yield:

α-diethoxyphosphoryl-α-benzyl-γ-phenyl-γ-butyrolactone (1008789-05-6) → trans-(1RS,2RS)-1-Benzyl-2-phenylcyclopropanecarboxylic acid

Guidance literature:

α-diethoxyphosphoryl-α-benzyl-γ-phenyl-γ-butyrolactone; With sodium hydride; In tetrahydrofuran; ethanol; for 8h; Heating;

Further stages.; hydrolysis;

DOI:10.1107/S0108270107050883

upstream raw materials:

(2-oxo-5-phenyltetrahydrofuran-3-yl)-phosphonic acid diethyl ester

benzyl bromide