(2-oxo-5-phenyltetrahydrofuran-3-yl)-phosphonic acid diethyl ester

Base Information

• Chemical Name: (2-oxo-5-phenyltetrahydrofuran-3-yl)-phosphonic acid diethyl ester
• CAS No.: 1008788-92-8
• Molecular Formula: C₁₄H₁₉O₅P
• Molecular Weight: 298.276
• Mol file: 1008788-92-8.mol

Synonyms:(2-oxo-5-phenyltetrahydrofuran-3-yl)-phosphonic acid diethyl ester

Chemical Property of (2-oxo-5-phenyltetrahydrofuran-3-yl)-phosphonic acid diethyl ester

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of (2-oxo-5-phenyltetrahydrofuran-3-yl)-phosphonic acid diethyl ester

There total 1 articles about (2-oxo-5-phenyltetrahydrofuran-3-yl)-phosphonic acid diethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

2-(diethoxyphosphoryl)-4-oxo-4-phenylbutyric acid ethyl ester (97554-76-2) → (2-oxo-5-phenyltetrahydrofuran-3-yl)-phosphonic acid diethyl ester (1008788-92-8)

Guidance literature:

2-(diethoxyphosphoryl)-4-oxo-4-phenylbutyric acid ethyl ester; With potassium borohydride; In methanol; at 0 ℃; for 1.25h;

With hydrogenchloride; In methanol; at 20 ℃; pH=2; Further stages.;

DOI:10.1039/b712145h

Reference yield: 89.0%

(2-oxo-5-phenyltetrahydrofuran-3-yl)-phosphonic acid diethyl ester (1008788-92-8) + prenyl bromide (870-63-3) → (3-(3-methylbut-2-enyl)-2-oxo-5-phenyltetrahydrofuran-3-yl)-phosphonic acid diethyl ester (1008789-07-8)

Guidance literature:

(2-oxo-5-phenyltetrahydrofuran-3-yl)-phosphonic acid diethyl ester; With lithium diisopropyl amide; In tetrahydrofuran; at 0 ℃; for 0.25h;

prenyl bromide; In tetrahydrofuran; at -70 - 20 ℃; for 21h; Further stages.;

DOI:10.1039/b712145h

Reference yield: 75.0%

(2-oxo-5-phenyltetrahydrofuran-3-yl)-phosphonic acid diethyl ester (1008788-92-8) + benzyl bromide (100-39-0) → α-diethoxyphosphoryl-α-benzyl-γ-phenyl-γ-butyrolactone (1008789-05-6)

Guidance literature:

(2-oxo-5-phenyltetrahydrofuran-3-yl)-phosphonic acid diethyl ester; With lithium diisopropyl amide; In tetrahydrofuran; at 0 ℃; for 0.25h;

benzyl bromide; In tetrahydrofuran; at -70 - 20 ℃; for 21h; Further stages.;

DOI:10.1039/b712145h

upstream raw materials:

2-(diethoxyphosphoryl)-4-oxo-4-phenylbutyric acid ethyl ester

Downstream raw materials:

ethyl rac-(1S,2S)-2-phenylcycloproanecarboxylate

α-diethoxyphosphoryl-α-benzyl-γ-phenyl-γ-butyrolactone

(3-(3-methylbut-2-enyl)-2-oxo-5-phenyltetrahydrofuran-3-yl)-phosphonic acid diethyl ester

(E)-α-benzylidene-γ-phenyl-γ-butyrolactone