Technology Process of 2-(tert-butyl)-5-(methoxymethyl)benzonitrile
There total 5 articles about 2-(tert-butyl)-5-(methoxymethyl)benzonitrile which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
palladium diacetate; caesium carbonate; ruphos;
In
1,4-dioxane; water;
at 100 ℃;
Inert atmosphere;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: sulfuric acid; silver(II) sulfate; bromine / 20 °C
2.1: N,N-dimethyl acetamide / 72 h / 150 °C
3.1: ammonium formate; palladium 10% on activated carbon / ethanol / 2 h / Reflux; Inert atmosphere
4.1: sodium nitrite; hydrogen bromide / water; acetonitrile / 0.25 h / 5 °C
4.2: 20 °C
5.1: palladium diacetate; ruphos; caesium carbonate / water; 1,4-dioxane / 100 °C / Inert atmosphere
With
silver(II) sulfate; sulfuric acid; palladium 10% on activated carbon; hydrogen bromide; bromine; ammonium formate; palladium diacetate; caesium carbonate; sodium nitrite; ruphos;
In
1,4-dioxane; ethanol; N,N-dimethyl acetamide; water; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: N,N-dimethyl acetamide / 72 h / 150 °C
2.1: ammonium formate; palladium 10% on activated carbon / ethanol / 2 h / Reflux; Inert atmosphere
3.1: sodium nitrite; hydrogen bromide / water; acetonitrile / 0.25 h / 5 °C
3.2: 20 °C
4.1: palladium diacetate; ruphos; caesium carbonate / water; 1,4-dioxane / 100 °C / Inert atmosphere
With
palladium 10% on activated carbon; hydrogen bromide; ammonium formate; palladium diacetate; caesium carbonate; sodium nitrite; ruphos;
In
1,4-dioxane; ethanol; N,N-dimethyl acetamide; water; acetonitrile;
