910251-11-5

Usage

Uses

Used in Organic Synthesis:
Potassium methoxy-methyltrifluoroborate is used as a reagent for the formation of carbon-carbon bonds through cross-coupling reactions. Its high reactivity and versatility make it suitable for a wide range of chemical transformations, contributing to the synthesis of complex organic molecules.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, potassium methoxy-methyltrifluoroborate is used as a reagent for the synthesis of various pharmaceutical compounds. Its ability to facilitate carbon-carbon bond formation aids in the creation of diverse molecular structures, which can be further utilized in the development of new drugs and therapeutic agents.
Used in Chemical Research:
Potassium methoxy-methyltrifluoroborate is employed as a research tool in chemical laboratories. Its unique properties and reactivity enable chemists to explore new reaction pathways and develop innovative synthetic methods, contributing to the advancement of chemical science.
Used in Material Science:
In the field of material science, potassium methoxy-methyltrifluoroborate is used as a reagent for the synthesis of novel materials with specific properties. Its ability to form carbon-carbon bonds can be leveraged to create new polymers, composites, or other materials with potential applications in various industries.
Overall, potassium methoxy-methyltrifluoroborate is a versatile and valuable compound in the field of organic chemistry, with applications spanning across various industries, including pharmaceuticals, chemical research, and material science. Its high reactivity and ability to facilitate carbon-carbon bond formation make it an essential tool for the synthesis of complex organic molecules and the development of innovative materials.

Upstream product

• 27490-32-0 tributyl(methoxymethyl)stannane 
• 124-41-4 sodium methylate 
• 67-56-1 methanol 

Downstream Products

• 1515-83-9 1-methoxymethyl-4-nitrobenzene 
• 21998-86-7 1-methoxy-2-methoxymethylbenzene 
• 22072-50-0 1-(4-(methoxymethyl)phenyl)ethanone 
• 1719-82-0 p-methoxymethylbenzoic acid methyl ester 
• 1515-81-7 1-methoxy-4-(methoxymethyl)benzene 
• 1379860-77-1 N,N-bis(4-methoxybenzyl)-4-(5-(methoxymethyl)-2-((6-methoxypyridin-3-yl)amino)pyridin-3-yl)-6-methyl-1,3,5-triazin-2-amine 
• 1610343-44-6 1-(1',4-dimethyl-1-phenyl-1H,1'H-[3,4'-bipyrazol]-5-yl)-3-(6-(methoxymethyl)isochroman-4-yl)urea 
• 1610343-47-9 1-(1',4-dimethyl-1-phenyl-1H,1'H-[3,4'-bipyrazol]-5-yl)-1-(6-(methoxymethyl)spiro[chroman-2,1'-cyclobutan]-4-yl)urea 
• 1610343-48-0 1-(1',4-dimethyl-1-phenyl-1H,1'H-[3,4'-bipyrazol]-5-yl)-1-(spiro[chroman-2,1'-cyclobutan]-4-yl)urea 

Relevant academic research and scientific papers

Catalytic, Enantioselective Addition of Alkyl Radicals to Alkenes via Visible-Light-Activated Photoredox Catalysis with a Chiral Rhodium Complex

An efficient enantioselective addition of alkyl radicals, oxidatively generated from organotrifluoroborates, to acceptor-substituted alkenes is catalyzed by a bis-cyclometalated rhodium catalyst (4 mol %) under photoredox conditions. The practical method provides yields up to 97% with excellent enantioselectivities up to 99% ee and can be classified as a redox neutral, electron-transfer-catalyzed reaction.

Cross-coupling of mesylated phenol derivatives with potassium alkoxymethyltrifluoroborates

Cross-coupling of mesylated phenol derivatives with various potassium alkoxymethyltrifluoroborates has been achieved. The corresponding aryl and heteroaryl alkoxymethyl compounds have been obtained with equal facility with both electron-rich and electron-poor substituents on the activated alcohol.

Preparation of potassium alkoxymethyltrifluoroborates and their cross-coupling with aryl chlorides

(Chemical Equation Presented) A wide variety of alkoxymethyltrifluoroborate substrates were prepared via SN2 displacement of potassium bromomethyltrifluoroborate with various alkoxides in excellent yields. These alkoxymethyltrifluoroborates were effectively cross-coupled with several aryl chlorides. This method provides a unique dissonant disconnect that allows greater flexibility in the design of new and improved synthetic pathways.

HYDROXYMETHYLBORON COMPOUNDS

The present invention provides compounds which are useful as safe substitutes for the organotin reagent used in coupling reaction for the oxymethylation of aromatic rings, such as alkoxymethylation or hydroxymethylation, with a palladium catalyst and which can dispense with chromatographic purification with silica gel in the production and are suitable for mass production; and compounds applicable even to the oxymethylation of aromatic ring substrates which do not permit coupling reaction by conventional technique or have low reactivity.