1-(toluene-4-sulfonyl)-1H-pyrrole-2-carboxylic acid methoxymethylamide

Base Information

• Chemical Name: 1-(toluene-4-sulfonyl)-1H-pyrrole-2-carboxylic acid methoxymethylamide
• CAS No.: 1222465-76-0
• Molecular Formula: C₁₄H₁₆N₂O₄S
• Molecular Weight: 308.358
• Mol file: 1222465-76-0.mol

Synonyms:1-(toluene-4-sulfonyl)-1H-pyrrole-2-carboxylic acid methoxymethylamide

Chemical Property of 1-(toluene-4-sulfonyl)-1H-pyrrole-2-carboxylic acid methoxymethylamide

Chemical Property:

Purity/Quality:

Safty Information:

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Technology Process of 1-(toluene-4-sulfonyl)-1H-pyrrole-2-carboxylic acid methoxymethylamide

There total 1 articles about 1-(toluene-4-sulfonyl)-1H-pyrrole-2-carboxylic acid methoxymethylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

p-toluenesulfonyl chloride (98-59-9) + 1H-pyrrole-2-carboxylic acid methoxymethylamide (368211-06-7) → 1-(toluene-4-sulfonyl)-1H-pyrrole-2-carboxylic acid methoxymethylamide (1222465-76-0)

Guidance literature:

1H-pyrrole-2-carboxylic acid methoxymethylamide; With sodium hydride; In tetrahydrofuran; mineral oil; at 0 ℃; for 0.166667h; Inert atmosphere;

p-toluenesulfonyl chloride; In tetrahydrofuran; mineral oil; at 20 ℃; for 5h; Inert atmosphere;

DOI:10.1021/ol102035s

Reference yield: 64.0%

1-(toluene-4-sulfonyl)-1H-pyrrole-2-carboxylic acid methoxymethylamide (1222465-76-0) + 2-methoxyphenylmagnesium bromide (16750-63-3) → (2-methoxyphenyl)(1-tosyl-1H-pyrrol-2-yl)methanone (1253122-29-0)

Guidance literature:

With sodium hydride; In tetrahydrofuran; diethyl ether; at -15 - 20 ℃; Inert atmosphere;

DOI:10.1021/ol102035s

Reference yield: 64.0%

1-(toluene-4-sulfonyl)-1H-pyrrole-2-carboxylic acid methoxymethylamide (1222465-76-0) + vinyl magnesium bromide (1826-67-1) → 1-[1-(toluene-4-sulfonyl)-1H-pyrrol-2-yl]propenone (1222465-41-9)

Guidance literature:

In tetrahydrofuran; at -78 - 20 ℃;

DOI:10.1073/pnas.0913466107

upstream raw materials:

p-toluenesulfonyl chloride

1H-pyrrole-2-carboxylic acid methoxymethylamide

Downstream raw materials:

1-[1-(toluene-4-sulfonyl)-1H-pyrrol-2-yl]propenone

(2-methoxyphenyl)(1-tosyl-1H-pyrrol-2-yl)methanone