1H-Pyrrole-2-carboxamide,N-methoxy-N-methyl-(9CI)

Base Information

• Chemical Name: 1H-Pyrrole-2-carboxamide,N-methoxy-N-methyl-(9CI)
• CAS No.: 368211-06-7
• Molecular Formula: C7H10 N2 O2
• Molecular Weight: 154.169
• Mol file: 368211-06-7.mol

Synonyms:1H-Pyrrole-2-carboxamide,N-methoxy-N-methyl-(9CI)

Chemical Property of 1H-Pyrrole-2-carboxamide,N-methoxy-N-methyl-(9CI)

Chemical Property:

• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

N-Methoxy-N-methyl-1H-pyrrole-2-carboxamide 98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1H-Pyrrole-2-carboxamide,N-methoxy-N-methyl-(9CI)

There total 5 articles about 1H-Pyrrole-2-carboxamide,N-methoxy-N-methyl-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

pyrrole (109-97-7,30604-81-0) + N,O-dimethylhydroxylamine*hydrochloride (6638-79-5) → 1H-pyrrole-2-carboxylic acid methoxymethylamide (368211-06-7)

Guidance literature:

pyrrole; With bis(trichloromethyl) carbonate; N,N-dimethyl-aniline; In toluene; at 0 - 20 ℃; for 2.33333h; Inert atmosphere;

N,O-dimethylhydroxylamine*hydrochloride; With triethylamine; In toluene; at 20 ℃; for 0.5h; Inert atmosphere;

DOI:10.1021/jo301835e

Reference yield: 96.0%

pyrrole-2-carboxyl acid (634-97-9) + N,0-dimethylhydroxylamine (1117-97-1) → 1H-pyrrole-2-carboxylic acid methoxymethylamide (368211-06-7)

Guidance literature:

pyrrole-2-carboxyl acid; With thionyl chloride; In toluene; for 3h; Heating;

N,0-dimethylhydroxylamine; With triethylamine; In dichloromethane; at 20 ℃; for 14h;

DOI:10.1021/ol034194+

Reference yield: 96.0%

methyl Pyrrole-2-carboxylate (1193-62-0) + N,O-dimethylhydroxylamine*hydrochloride (6638-79-5) → 1H-pyrrole-2-carboxylic acid methoxymethylamide (368211-06-7)

Guidance literature:

With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 0.5h; Inert atmosphere;

DOI:10.1021/ol102035s

upstream raw materials:

pyrrole-2-carboxyl acid

N,0-dimethylhydroxylamine

oxalyl dichloride

N,O-dimethylhydroxylamine*hydrochloride

Downstream raw materials:

1-(2-iodobenzyl)pyrrole-2-carboxylic acid methoxy methyl amide

(1,3-dibromo-4,5-dichloro-1H-pyrrol-2-yl)(2-methoxyphenyl)methanone

(3-bromo-4,5-dichloro-1H-pyrrol-2-yl)(2,3,4-trimethoxyphenyl)methanone

C₁₂H₈BrCl₂NO₄

Refernces

• 1、 Borrero, Nicholas V.,Aponick, Aaron. "Total synthesis of acortatarin A using a Pd(II)-catalyzed spiroketalization strategy". . p. 8410 - 8416,7. Retrieved 2020/09/15.
• 2、 Ruiz, Javier,Sotomayor, Nuria,Lete, Esther. "Parham-type cycliacylation with Weinreb amides. Application to the synthesis of fused indolizinone systems". . p. 1115 - 1117. Retrieved 2007/10/03.