(S)-6-amino-7-(4-phenoxyphenyl)-9-(pyrrolidin-2-ylmethyl)-7H-purin-8(9H)-one hydrochloride

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Chemical Name:(S)-6-amino-7-(4-phenoxyphenyl)-9-(pyrrolidin-2-ylmethyl)-7H-purin-8(9H)-one hydrochloride
CAS No.:1610473-57-8
Molecular Formula:C₂₂H₂₂N₆O₂*ClH
Molecular Weight:438.917
Hs Code.:

Synonyms:(S)-6-amino-7-(4-phenoxyphenyl)-9-(pyrrolidin-2-ylmethyl)-7H-purin-8(9H)-one hydrochloride

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Chemical Property of (S)-6-amino-7-(4-phenoxyphenyl)-9-(pyrrolidin-2-ylmethyl)-7H-purin-8(9H)-one hydrochloride

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Technology Process of (S)-6-amino-7-(4-phenoxyphenyl)-9-(pyrrolidin-2-ylmethyl)-7H-purin-8(9H)-one hydrochloride

There total 4 articles about (S)-6-amino-7-(4-phenoxyphenyl)-9-(pyrrolidin-2-ylmethyl)-7H-purin-8(9H)-one hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1610473-60-3
(S)-tert-butyl 2-((5-amino-6-(dibenzylamino)-pyrimidin-4-ylamino)methyl)pyrrolidine-1-carboxylate

: 1610473-57-8
(S)-6-amino-7-(4-phenoxyphenyl)-9-(pyrrolidin-2-ylmethyl)-7H-purin-8(9H)-one hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1: N-ethyl-N,N-diisopropylamine / 1,2-dichloro-ethane / 2 h / 100 °C / Sealed tube; Inert atmosphere

2: palladium 10% on activated carbon; hydrogen / acetic acid / 2.5 h / 90 °C / Autoclave; Inert atmosphere

3: pyridine; copper diacetate; oxygen / dichloromethane / 16 h / 20 °C

4: hydrogenchloride / 1,4-dioxane / 4 h / 15 - 20 °C / Inert atmosphere

With pyridine; hydrogenchloride; palladium 10% on activated carbon; hydrogen; oxygen; copper diacetate; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; dichloromethane; acetic acid; 1,2-dichloro-ethane;

Reference yield:

: 1610473-59-0
(S)-tert-butyl 2-((6-(dibenzylamino)-5-nitropyrimidin-4-ylamino)methyl)pyrrolidine-1-carboxylate

: 1610473-57-8
(S)-6-amino-7-(4-phenoxyphenyl)-9-(pyrrolidin-2-ylmethyl)-7H-purin-8(9H)-one hydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1: hydroxylamine hydrochloride; zinc / ethyl acetate; water / 2.5 h / 10 - 20 °C

2: N-ethyl-N,N-diisopropylamine / 1,2-dichloro-ethane / 2 h / 100 °C / Sealed tube; Inert atmosphere

3: palladium 10% on activated carbon; hydrogen / acetic acid / 2.5 h / 90 °C / Autoclave; Inert atmosphere

4: pyridine; copper diacetate; oxygen / dichloromethane / 16 h / 20 °C

5: hydrogenchloride / 1,4-dioxane / 4 h / 15 - 20 °C / Inert atmosphere

With pyridine; hydrogenchloride; palladium 10% on activated carbon; hydroxylamine hydrochloride; hydrogen; oxygen; copper diacetate; N-ethyl-N,N-diisopropylamine; zinc; In 1,4-dioxane; dichloromethane; water; acetic acid; ethyl acetate; 1,2-dichloro-ethane;

Reference yield:

: 1610473-61-4
(S)-tert-butyl 2-((6-(dibenzylamino)-8-oxo-7H-purin-9(8H)-yl)methyl)pyrrolidine-1-carboxylate

: 1610473-57-8
(S)-6-amino-7-(4-phenoxyphenyl)-9-(pyrrolidin-2-ylmethyl)-7H-purin-8(9H)-one hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: palladium 10% on activated carbon; hydrogen / acetic acid / 2.5 h / 90 °C / Autoclave; Inert atmosphere

2: pyridine; copper diacetate; oxygen / dichloromethane / 16 h / 20 °C

3: hydrogenchloride / 1,4-dioxane / 4 h / 15 - 20 °C / Inert atmosphere

With pyridine; hydrogenchloride; palladium 10% on activated carbon; hydrogen; oxygen; copper diacetate; In 1,4-dioxane; dichloromethane; acetic acid;