(S)-3-(2-((6-amino-8-oxo-7-(4-phenoxyphenyl)-7H-purin-9(8H)-yl)methyl)pyrrolidin-1-yl)-3-oxopropanenitrile

Base Information

Chemical Name:(S)-3-(2-((6-amino-8-oxo-7-(4-phenoxyphenyl)-7H-purin-9(8H)-yl)methyl)pyrrolidin-1-yl)-3-oxopropanenitrile
CAS No.:1610473-55-6
Molecular Formula:C₂₅H₂₃N₇O₃
Molecular Weight:469.503
Hs Code.:

Synonyms:(S)-3-(2-((6-amino-8-oxo-7-(4-phenoxyphenyl)-7H-purin-9(8H)-yl)methyl)pyrrolidin-1-yl)-3-oxopropanenitrile

Suppliers and Price of (S)-3-(2-((6-amino-8-oxo-7-(4-phenoxyphenyl)-7H-purin-9(8H)-yl)methyl)pyrrolidin-1-yl)-3-oxopropanenitrile

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (S)-3-(2-((6-amino-8-oxo-7-(4-phenoxyphenyl)-7H-purin-9(8H)-yl)methyl)pyrrolidin-1-yl)-3-oxopropanenitrile

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (S)-3-(2-((6-amino-8-oxo-7-(4-phenoxyphenyl)-7H-purin-9(8H)-yl)methyl)pyrrolidin-1-yl)-3-oxopropanenitrile

There total 6 articles about (S)-3-(2-((6-amino-8-oxo-7-(4-phenoxyphenyl)-7H-purin-9(8H)-yl)methyl)pyrrolidin-1-yl)-3-oxopropanenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1610473-57-8
(S)-6-amino-7-(4-phenoxyphenyl)-9-(pyrrolidin-2-ylmethyl)-7H-purin-8(9H)-one hydrochloride

: 372-09-8
cyanoacetic acid

: 1610473-55-6
(S)-3-(2-((6-amino-8-oxo-7-(4-phenoxyphenyl)-7H-purin-9(8H)-yl)methyl)pyrrolidin-1-yl)-3-oxopropanenitrile

Guidance literature:: cyanoacetic acid; With N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In N,N-dimethyl-formamide; at 0 ℃; for 0.5h; Inert atmosphere;

(S)-6-amino-7-(4-phenoxyphenyl)-9-(pyrrolidin-2-ylmethyl)-7H-purin-8(9H)-one hydrochloride; With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 0 - 20 ℃;

Reference yield:

: 1610473-61-4
(S)-tert-butyl 2-((6-(dibenzylamino)-8-oxo-7H-purin-9(8H)-yl)methyl)pyrrolidine-1-carboxylate

: 1610473-55-6
(S)-3-(2-((6-amino-8-oxo-7-(4-phenoxyphenyl)-7H-purin-9(8H)-yl)methyl)pyrrolidin-1-yl)-3-oxopropanenitrile

Guidance literature:: Multi-step reaction with 4 steps

1.1: palladium 10% on activated carbon; hydrogen / acetic acid / 2.5 h / 90 °C / Autoclave; Inert atmosphere

2.1: pyridine; copper diacetate; oxygen / dichloromethane / 16 h / 20 °C

3.1: hydrogenchloride / 1,4-dioxane / 4 h / 15 - 20 °C / Inert atmosphere

4.1: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 0.5 h / 0 °C / Inert atmosphere

4.2: 0 - 20 °C

With pyridine; hydrogenchloride; palladium 10% on activated carbon; hydrogen; oxygen; copper diacetate; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In 1,4-dioxane; dichloromethane; acetic acid; N,N-dimethyl-formamide;

Reference yield:

: 1610473-63-6
(S)-tert-butyl 2-((6-amino-8-oxo-7-(4-phenoxyphenyl)-7H-purin-9(8H)-yl)methyl)pyrrolidine-1-carboxylate

: 1610473-55-6
(S)-3-(2-((6-amino-8-oxo-7-(4-phenoxyphenyl)-7H-purin-9(8H)-yl)methyl)pyrrolidin-1-yl)-3-oxopropanenitrile

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrogenchloride / 1,4-dioxane / 4 h / 15 - 20 °C / Inert atmosphere

2.1: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 0.5 h / 0 °C / Inert atmosphere

2.2: 0 - 20 °C

With hydrogenchloride; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In 1,4-dioxane; N,N-dimethyl-formamide;