(S)-2-(2-((6-amino-8-oxo-7-(4-phenoxyphenyl)-7H-purin-9(8H)-yl)methyl)pyrrolidine-1-carbonyl)-4,4-dimethylpent-2-enenitrile

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Chemical Name:(S)-2-(2-((6-amino-8-oxo-7-(4-phenoxyphenyl)-7H-purin-9(8H)-yl)methyl)pyrrolidine-1-carbonyl)-4,4-dimethylpent-2-enenitrile
CAS No.:1610473-49-8
Molecular Formula:C₃₀H₃₁N₇O₃
Molecular Weight:537.621
Hs Code.:

Synonyms:(S)-2-(2-((6-amino-8-oxo-7-(4-phenoxyphenyl)-7H-purin-9(8H)-yl)methyl)pyrrolidine-1-carbonyl)-4,4-dimethylpent-2-enenitrile

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Chemical Property of (S)-2-(2-((6-amino-8-oxo-7-(4-phenoxyphenyl)-7H-purin-9(8H)-yl)methyl)pyrrolidine-1-carbonyl)-4,4-dimethylpent-2-enenitrile

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Technology Process of (S)-2-(2-((6-amino-8-oxo-7-(4-phenoxyphenyl)-7H-purin-9(8H)-yl)methyl)pyrrolidine-1-carbonyl)-4,4-dimethylpent-2-enenitrile

There total 7 articles about (S)-2-(2-((6-amino-8-oxo-7-(4-phenoxyphenyl)-7H-purin-9(8H)-yl)methyl)pyrrolidine-1-carbonyl)-4,4-dimethylpent-2-enenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 88319-37-3
2-cyano-4,4-dimethylpent-2-enoic acid

: 1610473-57-8
(S)-6-amino-7-(4-phenoxyphenyl)-9-(pyrrolidin-2-ylmethyl)-7H-purin-8(9H)-one hydrochloride

: 1610473-49-8
(S)-2-(2-((6-amino-8-oxo-7-(4-phenoxyphenyl)-7H-purin-9(8H)-yl)methyl)pyrrolidine-1-carbonyl)-4,4-dimethylpent-2-enenitrile

Guidance literature:: 2-cyano-4,4-dimethylpent-2-enoic acid; With N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In N,N-dimethyl-formamide; at 0 ℃; for 0.5h; Inert atmosphere;

(S)-6-amino-7-(4-phenoxyphenyl)-9-(pyrrolidin-2-ylmethyl)-7H-purin-8(9H)-one hydrochloride; With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 0 - 20 ℃;

Reference yield:

: 1610473-61-4
(S)-tert-butyl 2-((6-(dibenzylamino)-8-oxo-7H-purin-9(8H)-yl)methyl)pyrrolidine-1-carboxylate

: 1610473-49-8
(S)-2-(2-((6-amino-8-oxo-7-(4-phenoxyphenyl)-7H-purin-9(8H)-yl)methyl)pyrrolidine-1-carbonyl)-4,4-dimethylpent-2-enenitrile

Guidance literature:: Multi-step reaction with 4 steps

1.1: palladium 10% on activated carbon; hydrogen / acetic acid / 2.5 h / 90 °C / Autoclave; Inert atmosphere

2.1: pyridine; copper diacetate; oxygen / dichloromethane / 16 h / 20 °C

3.1: hydrogenchloride / 1,4-dioxane / 4 h / 15 - 20 °C / Inert atmosphere

4.1: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 0.5 h / 0 °C / Inert atmosphere

4.2: 0 - 20 °C

With pyridine; hydrogenchloride; palladium 10% on activated carbon; hydrogen; oxygen; copper diacetate; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In 1,4-dioxane; dichloromethane; acetic acid; N,N-dimethyl-formamide;

Reference yield:

: 1610473-63-6
(S)-tert-butyl 2-((6-amino-8-oxo-7-(4-phenoxyphenyl)-7H-purin-9(8H)-yl)methyl)pyrrolidine-1-carboxylate

: 1610473-49-8
(S)-2-(2-((6-amino-8-oxo-7-(4-phenoxyphenyl)-7H-purin-9(8H)-yl)methyl)pyrrolidine-1-carbonyl)-4,4-dimethylpent-2-enenitrile

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrogenchloride / 1,4-dioxane / 4 h / 15 - 20 °C / Inert atmosphere

2.1: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 0.5 h / 0 °C / Inert atmosphere

2.2: 0 - 20 °C

With hydrogenchloride; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In 1,4-dioxane; N,N-dimethyl-formamide;