(S)-tert-butyl 2-((6-(dibenzylamino)-5-nitropyrimidin-4-ylamino)methyl)pyrrolidine-1-carboxylate

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Chemical Name:(S)-tert-butyl 2-((6-(dibenzylamino)-5-nitropyrimidin-4-ylamino)methyl)pyrrolidine-1-carboxylate
CAS No.:1610473-59-0
Molecular Formula:C₂₈H₃₄N₆O₄
Molecular Weight:518.616
Hs Code.:

Synonyms:(S)-tert-butyl 2-((6-(dibenzylamino)-5-nitropyrimidin-4-ylamino)methyl)pyrrolidine-1-carboxylate

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Chemical Property of (S)-tert-butyl 2-((6-(dibenzylamino)-5-nitropyrimidin-4-ylamino)methyl)pyrrolidine-1-carboxylate

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Technology Process of (S)-tert-butyl 2-((6-(dibenzylamino)-5-nitropyrimidin-4-ylamino)methyl)pyrrolidine-1-carboxylate

There total 2 articles about (S)-tert-butyl 2-((6-(dibenzylamino)-5-nitropyrimidin-4-ylamino)methyl)pyrrolidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 882272-97-1
N,N-dibenzyl-6-chloro-5-nitropyrimidine-4-amine

: 119020-01-8
(S)-2-(aminomethyl)pyrrolidine-1-carboxylic acid tert-butyl ester

: 1610473-59-0
(S)-tert-butyl 2-((6-(dibenzylamino)-5-nitropyrimidin-4-ylamino)methyl)pyrrolidine-1-carboxylate

Guidance literature:: N,N-dibenzyl-6-chloro-5-nitropyrimidine-4-amine; With triethylamine; In 1,4-dioxane; at 20 ℃; for 0.166667h;

(S)-2-(aminomethyl)pyrrolidine-1-carboxylic acid tert-butyl ester; In 1,4-dioxane; at 20 ℃;

Reference yield:

: 103-49-1
dibenzylamine

: 1610473-59-0
(S)-tert-butyl 2-((6-(dibenzylamino)-5-nitropyrimidin-4-ylamino)methyl)pyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: dichloromethane / 1.5 h / 0 °C

2.1: triethylamine / 1,4-dioxane / 0.17 h / 20 °C

2.2: 20 °C

With triethylamine; In 1,4-dioxane; dichloromethane;

Reference yield:

: 1610473-59-0
(S)-tert-butyl 2-((6-(dibenzylamino)-5-nitropyrimidin-4-ylamino)methyl)pyrrolidine-1-carboxylate

: 1610473-50-1
(S)-2-(2-((6-amino-8-oxo-7-(4-phenoxyphenyl)-7H-purin-9(8H)-yl)methyl)-pyrrolidine-1-carbonyl)-4-methyl-4-morpholinopent-2-enenitrile

Guidance literature:: Multi-step reaction with 7 steps

1.1: hydroxylamine hydrochloride; zinc / ethyl acetate; water / 2.5 h / 10 - 20 °C

2.1: N-ethyl-N,N-diisopropylamine / 1,2-dichloro-ethane / 2 h / 100 °C / Sealed tube; Inert atmosphere

3.1: palladium 10% on activated carbon; hydrogen / acetic acid / 2.5 h / 90 °C / Autoclave; Inert atmosphere

4.1: pyridine; copper diacetate; oxygen / dichloromethane / 16 h / 20 °C

5.1: hydrogenchloride / 1,4-dioxane / 4 h / 15 - 20 °C / Inert atmosphere

6.1: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 0.5 h / 0 °C / Inert atmosphere

6.2: 0 - 20 °C

7.1: pyrrolidine; chloro-trimethyl-silane / N,N-dimethyl-formamide; acetonitrile / 2 h / 20 - 25 °C / Inert atmosphere

With pyrrolidine; pyridine; hydrogenchloride; chloro-trimethyl-silane; palladium 10% on activated carbon; hydroxylamine hydrochloride; hydrogen; oxygen; copper diacetate; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; zinc; In 1,4-dioxane; dichloromethane; water; acetic acid; ethyl acetate; 1,2-dichloro-ethane; N,N-dimethyl-formamide; acetonitrile;