(S)-3-(5-bromo-2,4-difluorophenyl)-3-((R)-1,1-dimethylethylsulfinamido)-N-methoxy-N-methylbutanamide

Base Information

Chemical Name:(S)-3-(5-bromo-2,4-difluorophenyl)-3-((R)-1,1-dimethylethylsulfinamido)-N-methoxy-N-methylbutanamide
CAS No.:1194044-90-0
Molecular Formula:C₁₆H₂₃BrF₂N₂O₃S
Molecular Weight:441.337
Hs Code.:

Synonyms:(S)-3-(5-bromo-2,4-difluorophenyl)-3-((R)-1,1-dimethylethylsulfinamido)-N-methoxy-N-methylbutanamide

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Chemical Property of (S)-3-(5-bromo-2,4-difluorophenyl)-3-((R)-1,1-dimethylethylsulfinamido)-N-methoxy-N-methylbutanamide

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Technology Process of (S)-3-(5-bromo-2,4-difluorophenyl)-3-((R)-1,1-dimethylethylsulfinamido)-N-methoxy-N-methylbutanamide

There total 2 articles about (S)-3-(5-bromo-2,4-difluorophenyl)-3-((R)-1,1-dimethylethylsulfinamido)-N-methoxy-N-methylbutanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 1194044-31-9
(S)-methyl 3-(5-bromo-2,4-difluorophenyl)-3-((R)-1,1-dimethylethylsulfinamido)butanoate

: 6638-79-5
N,O-dimethylhydroxylamine*hydrochloride

: 1194044-90-0
(S)-3-(5-bromo-2,4-difluorophenyl)-3-((R)-1,1-dimethylethylsulfinamido)-N-methoxy-N-methylbutanamide

Guidance literature:: With n-butyllithium; In tetrahydrofuran; at -60 ℃;
DOI:10.1016/j.tetlet.2014.02.053

Reference yield:

: 1194044-22-8
(R)-2-methyl-propane-2-sulfinic acid [1-(5-bromo-2,4-difluoro-phenyl)-ethylidene]-amide

: 1194044-90-0
(S)-3-(5-bromo-2,4-difluorophenyl)-3-((R)-1,1-dimethylethylsulfinamido)-N-methoxy-N-methylbutanamide

Guidance literature:: Multi-step reaction with 2 steps

1: triisopropoxytitanium(IV) chloride; lithium diisopropyl amide / tetrahydrofuran / -78 °C

2: n-butyllithium / tetrahydrofuran / -60 °C

With triisopropoxytitanium(IV) chloride; n-butyllithium; lithium diisopropyl amide; In tetrahydrofuran;
DOI:10.1016/j.tetlet.2014.02.053