1-cyclopropyl-3-(3-fluoro-4-(2-(5-(morpholinomethyl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yloxy)phenyl)urea

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Chemical Name:1-cyclopropyl-3-(3-fluoro-4-(2-(5-(morpholinomethyl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yloxy)phenyl)urea
CAS No.:1187212-88-9
Molecular Formula:C₂₇H₂₆FN₅O₃S
Molecular Weight:519.6
Hs Code.:

Synonyms:1-cyclopropyl-3-(3-fluoro-4-(2-(5-(morpholinomethyl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yloxy)phenyl)urea

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Chemical Property of 1-cyclopropyl-3-(3-fluoro-4-(2-(5-(morpholinomethyl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yloxy)phenyl)urea

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Technology Process of 1-cyclopropyl-3-(3-fluoro-4-(2-(5-(morpholinomethyl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yloxy)phenyl)urea

There total 6 articles about 1-cyclopropyl-3-(3-fluoro-4-(2-(5-(morpholinomethyl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yloxy)phenyl)urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 18.53%

: 32315-10-9
bis(trichloromethyl) carbonate

: 1187214-13-6
3-fluoro-4-(2-(5-(morpholinomethyl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yloxy)aniline

: 765-30-0
Cyclopropylamine

: 1187212-88-9
1-cyclopropyl-3-(3-fluoro-4-(2-(5-(morpholinomethyl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yloxy)phenyl)urea

Guidance literature:: bis(trichloromethyl) carbonate; 3-fluoro-4-(2-(5-(morpholinomethyl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yloxy)aniline; With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 0 ℃; for 1h;

Cyclopropylamine; In tetrahydrofuran; at 20 ℃; for 3h;

Reference yield:

: 149806-06-4
6-bromonicotinaldehyde

: 1187212-88-9
1-cyclopropyl-3-(3-fluoro-4-(2-(5-(morpholinomethyl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yloxy)phenyl)urea

Guidance literature:: Multi-step reaction with 7 steps

1.1: camphor-10-sulfonic acid / toluene / 0.83 h / Reflux

2.1: n-butyllithium / tetrahydrofuran; hexanes / 1.33 h / -10 - -5 °C

2.2: 1.58 h / -10 - 20 °C

2.3: 2 h / Reflux

3.1: sodium carbonate / diphenylether / 2 h / 180 °C

4.1: water; acetic acid / 18 h / 90 °C

5.1: acetic acid / dichloromethane / 1 h / 20 °C

6.1: iron; ammonium chloride / ethanol; water / 0.5 h / 80 °C

7.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 1 h / 0 °C

7.2: 3 h / 20 °C

With n-butyllithium; water; iron; sodium carbonate; ammonium chloride; acetic acid; N-ethyl-N,N-diisopropylamine; camphor-10-sulfonic acid; In tetrahydrofuran; hexanes; diphenylether; ethanol; dichloromethane; water; toluene;

Reference yield:

: 918643-34-2
6-(7-(2-fluoro-4-nitrophenoxy)thieno[3,2-b]pyridin-2-yl)nicotinaldehyde

: 1187212-88-9
1-cyclopropyl-3-(3-fluoro-4-(2-(5-(morpholinomethyl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yloxy)phenyl)urea

Guidance literature:: Multi-step reaction with 3 steps

1.1: acetic acid / dichloromethane / 1 h / 20 °C

2.1: iron; ammonium chloride / ethanol; water / 0.5 h / 80 °C

3.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 1 h / 0 °C

3.2: 3 h / 20 °C

With iron; ammonium chloride; acetic acid; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; ethanol; dichloromethane; water;