3-fluoro-4-(2-(5-(morpholinomethyl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yloxy)aniline

Base Information

Chemical Name:3-fluoro-4-(2-(5-(morpholinomethyl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yloxy)aniline
CAS No.:1187214-13-6
Molecular Formula:C₂₃H₂₁FN₄O₂S
Molecular Weight:436.51
Hs Code.:

Synonyms:3-fluoro-4-(2-(5-(morpholinomethyl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yloxy)aniline

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Chemical Property of 3-fluoro-4-(2-(5-(morpholinomethyl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yloxy)aniline

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Technology Process of 3-fluoro-4-(2-(5-(morpholinomethyl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yloxy)aniline

There total 5 articles about 3-fluoro-4-(2-(5-(morpholinomethyl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yloxy)aniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 33.6%

: 1187214-12-5
4-((6-(7-(2-fluoro-4-nitrophenoxy)thieno[3,2-b]pyridin-2-yl)pyridin-3-yl)methyl)morpholine

: 1187214-13-6
3-fluoro-4-(2-(5-(morpholinomethyl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yloxy)aniline

Guidance literature:: With iron; ammonium chloride; In ethanol; water; at 80 ℃; for 0.5h;

Reference yield:

: 149806-06-4
6-bromonicotinaldehyde

: 1187214-13-6
3-fluoro-4-(2-(5-(morpholinomethyl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yloxy)aniline

Guidance literature:: Multi-step reaction with 6 steps

1.1: camphor-10-sulfonic acid / toluene / 0.83 h / Reflux

2.1: n-butyllithium / tetrahydrofuran; hexanes / 1.33 h / -10 - -5 °C

2.2: 1.58 h / -10 - 20 °C

2.3: 2 h / Reflux

3.1: sodium carbonate / diphenylether / 2 h / 180 °C

4.1: water; acetic acid / 18 h / 90 °C

5.1: acetic acid / dichloromethane / 1 h / 20 °C

6.1: iron; ammonium chloride / ethanol; water / 0.5 h / 80 °C

With n-butyllithium; water; iron; sodium carbonate; ammonium chloride; acetic acid; camphor-10-sulfonic acid; In tetrahydrofuran; hexanes; diphenylether; ethanol; dichloromethane; water; toluene;

Reference yield:

: 918643-34-2
6-(7-(2-fluoro-4-nitrophenoxy)thieno[3,2-b]pyridin-2-yl)nicotinaldehyde

: 1187214-13-6
3-fluoro-4-(2-(5-(morpholinomethyl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yloxy)aniline

Guidance literature:: Multi-step reaction with 2 steps

1: acetic acid / dichloromethane / 1 h / 20 °C

2: iron; ammonium chloride / ethanol; water / 0.5 h / 80 °C

With iron; ammonium chloride; acetic acid; In ethanol; dichloromethane; water;