6-amino-6-[(1R,4R)-4-(methoxycarbonyl)cyclohexane-1-yl]-tetrahydro-1H-1,4-diazepine

Base Information

Chemical Name:6-amino-6-[(1R,4R)-4-(methoxycarbonyl)cyclohexane-1-yl]-tetrahydro-1H-1,4-diazepine
CAS No.:1456626-18-8
Molecular Formula:C₁₃H₂₅N₃O₂
Molecular Weight:255.36
Hs Code.:

Synonyms:6-amino-6-[(1R,4R)-4-(methoxycarbonyl)cyclohexane-1-yl]-tetrahydro-1H-1,4-diazepine

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Chemical Property of 6-amino-6-[(1R,4R)-4-(methoxycarbonyl)cyclohexane-1-yl]-tetrahydro-1H-1,4-diazepine

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Technology Process of 6-amino-6-[(1R,4R)-4-(methoxycarbonyl)cyclohexane-1-yl]-tetrahydro-1H-1,4-diazepine

There total 6 articles about 6-amino-6-[(1R,4R)-4-(methoxycarbonyl)cyclohexane-1-yl]-tetrahydro-1H-1,4-diazepine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 1456626-17-7
6-[(1R,4R)-4-(methoxycarbonyl)cyclohexane-1-yl]-6-nitro-1,4-bis(phenylmethyl)-tetrahydro-1H-1,4-diazepine

: 1456626-18-8
6-amino-6-[(1R,4R)-4-(methoxycarbonyl)cyclohexane-1-yl]-tetrahydro-1H-1,4-diazepine

Guidance literature:: With 5%-palladium/activated carbon; hydrogen; In tetrahydrofuran; methanol; at 40 ℃; for 11h;

Reference yield:

: 110928-44-4
trans-(4-hydroxymethyl)cyclohexane-1-carboxylic acid methyl ester

: 1456626-18-8
6-amino-6-[(1R,4R)-4-(methoxycarbonyl)cyclohexane-1-yl]-tetrahydro-1H-1,4-diazepine

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine / tetrahydrofuran / 2.17 h / 0 - 20 °C

2.1: sodium iodide / acetone; diethyl ether / 72.5 h / 20 °C / Reflux

3.1: sodium nitrite; 3,5-dihydroxyphenol / dimethyl sulfoxide / 48 h / 20 °C / Inert atmosphere

4.1: ethanol / 1.5 h / 60 - 80 °C

4.2: 6 h / 80 °C

5.1: hydrogen; 5%-palladium/activated carbon / tetrahydrofuran; methanol / 11 h / 40 °C

With 3,5-dihydroxyphenol; 5%-palladium/activated carbon; hydrogen; triethylamine; sodium iodide; sodium nitrite; In tetrahydrofuran; methanol; diethyl ether; ethanol; dimethyl sulfoxide; acetone;

Reference yield:

: 213413-28-6
(1R,4R)-4-(iodomethyl)cyclohexanecarboxylic acid methyl ester

: 1456626-18-8
6-amino-6-[(1R,4R)-4-(methoxycarbonyl)cyclohexane-1-yl]-tetrahydro-1H-1,4-diazepine

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium nitrite; 3,5-dihydroxyphenol / dimethyl sulfoxide / 48 h / 20 °C / Inert atmosphere

2.1: ethanol / 1.5 h / 60 - 80 °C

2.2: 6 h / 80 °C

3.1: hydrogen; 5%-palladium/activated carbon / tetrahydrofuran; methanol / 11 h / 40 °C

With 3,5-dihydroxyphenol; 5%-palladium/activated carbon; hydrogen; sodium nitrite; In tetrahydrofuran; methanol; ethanol; dimethyl sulfoxide;