2,2,2-trifluoro-N-(1-{1-formyl-2-[4-(3-methyl-but-2-enyloxy)-phenyl]-ethyl}-8-oxo-1-aza-spiro[4.5]dec-3-yl)-N-methyl-acetamide

Base Information

Chemical Name:2,2,2-trifluoro-N-(1-{1-formyl-2-[4-(3-methyl-but-2-enyloxy)-phenyl]-ethyl}-8-oxo-1-aza-spiro[4.5]dec-3-yl)-N-methyl-acetamide
CAS No.:361520-03-8
Molecular Formula:C₂₆H₃₃F₃N₂O₄
Molecular Weight:494.554
Hs Code.:

2,2,2-trifluoro-<i>N</i>-(1-{1-formyl-2-[4-(3-methyl-but-2-enyloxy)-phenyl]-ethyl}-8-oxo-1-aza-spiro[4.5]dec-3-yl)-<i>N</i>-methyl-acetamide

Synonyms:2,2,2-trifluoro-N-(1-{1-formyl-2-[4-(3-methyl-but-2-enyloxy)-phenyl]-ethyl}-8-oxo-1-aza-spiro[4.5]dec-3-yl)-N-methyl-acetamide

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Chemical Property of 2,2,2-trifluoro-N-(1-{1-formyl-2-[4-(3-methyl-but-2-enyloxy)-phenyl]-ethyl}-8-oxo-1-aza-spiro[4.5]dec-3-yl)-N-methyl-acetamide

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Technology Process of 2,2,2-trifluoro-N-(1-{1-formyl-2-[4-(3-methyl-but-2-enyloxy)-phenyl]-ethyl}-8-oxo-1-aza-spiro[4.5]dec-3-yl)-N-methyl-acetamide

There total 16 articles about 2,2,2-trifluoro-N-(1-{1-formyl-2-[4-(3-methyl-but-2-enyloxy)-phenyl]-ethyl}-8-oxo-1-aza-spiro[4.5]dec-3-yl)-N-methyl-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 407-25-0
trifluoroacetic anhydride

: 361520-01-6
(3S,1S')-1-{2'-hydroxy-1'-[4-(3-methyl-but-2-enyloxy)benzyl]-ethyl}-3-[N-methyl-amino]-1-azaspiro[4.5]decane-8-ol

: 361520-03-8
2,2,2-trifluoro-N-(1-{1-formyl-2-[4-(3-methyl-but-2-enyloxy)-phenyl]-ethyl}-8-oxo-1-aza-spiro[4.5]dec-3-yl)-N-methyl-acetamide

Guidance literature:: With triethylamine; In dichloromethane; dimethyl sulfoxide; at -78 ℃;
DOI:10.1021/ja016030z

Reference yield:

: 361520-05-0
(S)-2-[(methoxycarbonyl)amino]-3-(4-methoxyphenyl) propan-1-ol

: 361520-03-8
2,2,2-trifluoro-N-(1-{1-formyl-2-[4-(3-methyl-but-2-enyloxy)-phenyl]-ethyl}-8-oxo-1-aza-spiro[4.5]dec-3-yl)-N-methyl-acetamide

Guidance literature:: Multi-step reaction with 11 steps

1: 86 percent / aq. KOH / 50 °C

2: 73 percent / triphenylphosphine; NEt₃; pyridine / CCl₄; acetonitrile / 24 h / 27 - 30 °C

3: iodobenzene diacetate; 2,2,2-trifluoroethanol / 0.5 h / 20 °C

4: 0.48 g / pyridine; DMAP / 20 °C

5: 96 percent / H₂; PtO₂ / ethyl acetate / 20 °C / 760.05 Torr

6: 79 percent / K₂CO₃ / methanol

7: 97 percent / K₂CO₃ / acetone; dimethylformamide

8: 87 percent / BBr₃ / CH₂Cl₂ / 1 h / -60 - 0 °C

9: 98 percent / Cs₂CO₃ / acetone / 2 h / 50 °C

10: LiAlH₄ / tetrahydrofuran / 48 h / Heating

11: Et₃N / dimethylsulfoxide; CH₂Cl₂ / -78 °C

With pyridine; dmap; platinum(IV) oxide; potassium hydroxide; lithium aluminium tetrahydride; 2,2,2-trifluoroethanol; [bis(acetoxy)iodo]benzene; hydrogen; boron tribromide; potassium carbonate; caesium carbonate; triethylamine; triphenylphosphine; In tetrahydrofuran; methanol; tetrachloromethane; dichloromethane; dimethyl sulfoxide; ethyl acetate; N,N-dimethyl-formamide; acetone; acetonitrile;
DOI:10.1021/ja016030z

Reference yield:

: 4703-32-6
(S)-2-[N-(4-methylphenyl)sulfonylamino]-3-(4-hydroxyphenyl) propionic acid

: 361520-03-8
2,2,2-trifluoro-N-(1-{1-formyl-2-[4-(3-methyl-but-2-enyloxy)-phenyl]-ethyl}-8-oxo-1-aza-spiro[4.5]dec-3-yl)-N-methyl-acetamide

Guidance literature:: Multi-step reaction with 10 steps

1: 73 percent / triphenylphosphine; NEt₃; pyridine / CCl₄; acetonitrile / 24 h / 27 - 30 °C

2: iodobenzene diacetate; 2,2,2-trifluoroethanol / 0.5 h / 20 °C

3: 0.48 g / pyridine; DMAP / 20 °C

4: 96 percent / H₂; PtO₂ / ethyl acetate / 20 °C / 760.05 Torr

5: 79 percent / K₂CO₃ / methanol

6: 97 percent / K₂CO₃ / acetone; dimethylformamide

7: 87 percent / BBr₃ / CH₂Cl₂ / 1 h / -60 - 0 °C

8: 98 percent / Cs₂CO₃ / acetone / 2 h / 50 °C

9: LiAlH₄ / tetrahydrofuran / 48 h / Heating

10: Et₃N / dimethylsulfoxide; CH₂Cl₂ / -78 °C

With pyridine; dmap; platinum(IV) oxide; lithium aluminium tetrahydride; 2,2,2-trifluoroethanol; [bis(acetoxy)iodo]benzene; hydrogen; boron tribromide; potassium carbonate; caesium carbonate; triethylamine; triphenylphosphine; In tetrahydrofuran; methanol; tetrachloromethane; dichloromethane; dimethyl sulfoxide; ethyl acetate; N,N-dimethyl-formamide; acetone; acetonitrile;
DOI:10.1021/ja016030z