(3S,1S')-1-{2'-hydroxy-1'-[4-(3-methyl-but-2-enyloxy)benzyl]-ethyl}-3-[N-methyl-amino]-1-azaspiro[4.5]decane-8-ol

Base Information

Chemical Name:(3S,1S')-1-{2'-hydroxy-1'-[4-(3-methyl-but-2-enyloxy)benzyl]-ethyl}-3-[N-methyl-amino]-1-azaspiro[4.5]decane-8-ol
CAS No.:361520-01-6
Molecular Formula:C₂₄H₃₈N₂O₃
Molecular Weight:402.577
Hs Code.:

Synonyms:(3S,1S')-1-{2'-hydroxy-1'-[4-(3-methyl-but-2-enyloxy)benzyl]-ethyl}-3-[N-methyl-amino]-1-azaspiro[4.5]decane-8-ol

Suppliers and Price of (3S,1S')-1-{2'-hydroxy-1'-[4-(3-methyl-but-2-enyloxy)benzyl]-ethyl}-3-[N-methyl-amino]-1-azaspiro[4.5]decane-8-ol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (3S,1S')-1-{2'-hydroxy-1'-[4-(3-methyl-but-2-enyloxy)benzyl]-ethyl}-3-[N-methyl-amino]-1-azaspiro[4.5]decane-8-ol

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (3S,1S')-1-{2'-hydroxy-1'-[4-(3-methyl-but-2-enyloxy)benzyl]-ethyl}-3-[N-methyl-amino]-1-azaspiro[4.5]decane-8-ol

There total 15 articles about (3S,1S')-1-{2'-hydroxy-1'-[4-(3-methyl-but-2-enyloxy)benzyl]-ethyl}-3-[N-methyl-amino]-1-azaspiro[4.5]decane-8-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 361520-00-5
(3S,1S')-1-{2'-hydroxy-1'-[4-(3-methyl-but-2-enyloxy)benzyl]-ethyl}-3-[N-methyl-N-(4-methylphenyl)sulfonylamino]-1-azaspiro[4.5]decan-2,8-dione

: 361520-01-6
(3S,1S')-1-{2'-hydroxy-1'-[4-(3-methyl-but-2-enyloxy)benzyl]-ethyl}-3-[N-methyl-amino]-1-azaspiro[4.5]decane-8-ol

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; for 48h; Heating;
DOI:10.1021/ja016030z

Reference yield:

: 361520-05-0
(S)-2-[(methoxycarbonyl)amino]-3-(4-methoxyphenyl) propan-1-ol

: 361520-01-6
(3S,1S')-1-{2'-hydroxy-1'-[4-(3-methyl-but-2-enyloxy)benzyl]-ethyl}-3-[N-methyl-amino]-1-azaspiro[4.5]decane-8-ol

Guidance literature:: Multi-step reaction with 10 steps

1: 86 percent / aq. KOH / 50 °C

2: 73 percent / triphenylphosphine; NEt₃; pyridine / CCl₄; acetonitrile / 24 h / 27 - 30 °C

3: iodobenzene diacetate; 2,2,2-trifluoroethanol / 0.5 h / 20 °C

4: 0.48 g / pyridine; DMAP / 20 °C

5: 96 percent / H₂; PtO₂ / ethyl acetate / 20 °C / 760.05 Torr

6: 79 percent / K₂CO₃ / methanol

7: 97 percent / K₂CO₃ / acetone; dimethylformamide

8: 87 percent / BBr₃ / CH₂Cl₂ / 1 h / -60 - 0 °C

9: 98 percent / Cs₂CO₃ / acetone / 2 h / 50 °C

10: LiAlH₄ / tetrahydrofuran / 48 h / Heating

With pyridine; dmap; platinum(IV) oxide; potassium hydroxide; lithium aluminium tetrahydride; 2,2,2-trifluoroethanol; [bis(acetoxy)iodo]benzene; hydrogen; boron tribromide; potassium carbonate; caesium carbonate; triethylamine; triphenylphosphine; In tetrahydrofuran; methanol; tetrachloromethane; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; acetone; acetonitrile;
DOI:10.1021/ja016030z

Reference yield:

: 4703-32-6
(S)-2-[N-(4-methylphenyl)sulfonylamino]-3-(4-hydroxyphenyl) propionic acid

: 361520-01-6
(3S,1S')-1-{2'-hydroxy-1'-[4-(3-methyl-but-2-enyloxy)benzyl]-ethyl}-3-[N-methyl-amino]-1-azaspiro[4.5]decane-8-ol

Guidance literature:: Multi-step reaction with 9 steps

1: 73 percent / triphenylphosphine; NEt₃; pyridine / CCl₄; acetonitrile / 24 h / 27 - 30 °C

2: iodobenzene diacetate; 2,2,2-trifluoroethanol / 0.5 h / 20 °C

3: 0.48 g / pyridine; DMAP / 20 °C

4: 96 percent / H₂; PtO₂ / ethyl acetate / 20 °C / 760.05 Torr

5: 79 percent / K₂CO₃ / methanol

6: 97 percent / K₂CO₃ / acetone; dimethylformamide

7: 87 percent / BBr₃ / CH₂Cl₂ / 1 h / -60 - 0 °C

8: 98 percent / Cs₂CO₃ / acetone / 2 h / 50 °C

9: LiAlH₄ / tetrahydrofuran / 48 h / Heating

With pyridine; dmap; platinum(IV) oxide; lithium aluminium tetrahydride; 2,2,2-trifluoroethanol; [bis(acetoxy)iodo]benzene; hydrogen; boron tribromide; potassium carbonate; caesium carbonate; triethylamine; triphenylphosphine; In tetrahydrofuran; methanol; tetrachloromethane; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; acetone; acetonitrile;
DOI:10.1021/ja016030z