Technology Process of tert-butyl N-cyclobutylmethyl-N-7-[2,6-dimethoxy-4-(methoxymethyl)phenyl]-2-ethylpyrazolo[1,5-a]pyridin-3-ylcarbamate
There total 14 articles about tert-butyl N-cyclobutylmethyl-N-7-[2,6-dimethoxy-4-(methoxymethyl)phenyl]-2-ethylpyrazolo[1,5-a]pyridin-3-ylcarbamate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
sodium hydride;
In
DMF (N,N-dimethyl-formamide);
at 20 ℃;
for 1h;
- Guidance literature:
-
Multi-step reaction with 2 steps
1: barium dihydroxide / tetrakis(triphenylphosphine) palladium(0) / 1,2-dimethoxyethane; water / 3 h / 80 °C
2: sodium hydride / DMF (N,N-dimethyl-formamide) / 1 h / 20 °C
With
barium dihydroxide; sodium hydride;
tetrakis(triphenylphosphine) palladium(0);
In
DMF (N,N-dimethyl-formamide); 1,2-dimethoxyethane; water;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -70 - -60 °C
1.2: 2 h / -70 - 20 °C
2.1: sulfuric acid; nitric acid / 0.5 h / 30 °C
3.1: acetic acid; zinc / ethanol; water / 1 h / 65 °C
4.1: triethylamine / dichloromethane / 15 h / 20 °C
5.1: barium dihydroxide / tetrakis(triphenylphosphine) palladium(0) / 1,2-dimethoxyethane; water / 3 h / 80 °C
6.1: sodium hydride / DMF (N,N-dimethyl-formamide) / 1 h / 20 °C
With
barium dihydroxide; n-butyllithium; sulfuric acid; nitric acid; sodium hydride; acetic acid; triethylamine; zinc;
tetrakis(triphenylphosphine) palladium(0);
In
tetrahydrofuran; DMF (N,N-dimethyl-formamide); 1,2-dimethoxyethane; ethanol; hexane; dichloromethane; water;