tert-butyl N-cyclobutylmethyl-N-7-[2,6-dimethoxy-4-(methoxymethyl)phenyl]-2-ethylpyrazolo[1,5-a]pyridin-3-ylcarbamate

Base Information

Chemical Name:tert-butyl N-cyclobutylmethyl-N-7-[2,6-dimethoxy-4-(methoxymethyl)phenyl]-2-ethylpyrazolo[1,5-a]pyridin-3-ylcarbamate
CAS No.:1226529-17-4
Molecular Formula:C₂₉H₃₉N₃O₅
Molecular Weight:509.646
Hs Code.:

Synonyms:tert-butyl N-cyclobutylmethyl-N-7-[2,6-dimethoxy-4-(methoxymethyl)phenyl]-2-ethylpyrazolo[1,5-a]pyridin-3-ylcarbamate

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Chemical Property of tert-butyl N-cyclobutylmethyl-N-7-[2,6-dimethoxy-4-(methoxymethyl)phenyl]-2-ethylpyrazolo[1,5-a]pyridin-3-ylcarbamate

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Technology Process of tert-butyl N-cyclobutylmethyl-N-7-[2,6-dimethoxy-4-(methoxymethyl)phenyl]-2-ethylpyrazolo[1,5-a]pyridin-3-ylcarbamate

There total 14 articles about tert-butyl N-cyclobutylmethyl-N-7-[2,6-dimethoxy-4-(methoxymethyl)phenyl]-2-ethylpyrazolo[1,5-a]pyridin-3-ylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 17247-58-4
(Bromomethyl)cyclobutane

: tert-butyl (7-(2,6-dimethoxy-4-(methoxymethyl)phenyl)-2-ethylpyrazolo[1,5-a]pyridin-3-yl)carbamate

: 1226529-17-4
tert-butyl N-cyclobutylmethyl-N-7-[2,6-dimethoxy-4-(methoxymethyl)phenyl]-2-ethylpyrazolo[1,5-a]pyridin-3-ylcarbamate

Guidance literature:: With sodium hydride; In DMF (N,N-dimethyl-formamide); at 20 ℃; for 1h;

Reference yield:

: 685886-67-3
[2,6-dimethoxy-4-(methoxymethyl)phenyl]boronic acid

: 1226529-17-4
tert-butyl N-cyclobutylmethyl-N-7-[2,6-dimethoxy-4-(methoxymethyl)phenyl]-2-ethylpyrazolo[1,5-a]pyridin-3-ylcarbamate

Guidance literature:: Multi-step reaction with 2 steps

1: barium dihydroxide / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 3 h / 80 °C

2: sodium hydride / DMF (N,N-dimethyl-formamide) / 1 h / 20 °C

With barium dihydroxide; sodium hydride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In DMF (N,N-dimethyl-formamide); 1,2-dimethoxyethane; water;

Reference yield:

: 475174-65-3
2-ethylpyrazolo[1,5-a]pyridine

: 1226529-17-4
tert-butyl N-cyclobutylmethyl-N-7-[2,6-dimethoxy-4-(methoxymethyl)phenyl]-2-ethylpyrazolo[1,5-a]pyridin-3-ylcarbamate

Guidance literature:: Multi-step reaction with 6 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -70 - -60 °C

1.2: 2 h / -70 - 20 °C

2.1: sulfuric acid; nitric acid / 0.5 h / 30 °C

3.1: acetic acid; zinc / ethanol; water / 1 h / 65 °C

4.1: triethylamine / dichloromethane / 15 h / 20 °C

5.1: barium dihydroxide / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 3 h / 80 °C

6.1: sodium hydride / DMF (N,N-dimethyl-formamide) / 1 h / 20 °C

With barium dihydroxide; n-butyllithium; sulfuric acid; nitric acid; sodium hydride; acetic acid; triethylamine; zinc; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; DMF (N,N-dimethyl-formamide); 1,2-dimethoxyethane; ethanol; hexane; dichloromethane; water;