Pyrazolo[1,5-a]pyridin-3-amine, 7-[2,6-dimethoxy-4-(methoxymethyl)phenyl]-2-ethyl-

Base Information

Chemical Name:Pyrazolo[1,5-a]pyridin-3-amine, 7-[2,6-dimethoxy-4-(methoxymethyl)phenyl]-2-ethyl-
CAS No.:685885-89-6
Molecular Formula:C19H23N3O3
Molecular Weight:341.41
Hs Code.:

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Pyrazolo[1,5-a]pyridin-3-amine, 7-[2,6-dimethoxy-4-(methoxymethyl)phenyl]-2-ethyl-

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

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Technology Process of Pyrazolo[1,5-a]pyridin-3-amine, 7-[2,6-dimethoxy-4-(methoxymethyl)phenyl]-2-ethyl-

There total 12 articles about Pyrazolo[1,5-a]pyridin-3-amine, 7-[2,6-dimethoxy-4-(methoxymethyl)phenyl]-2-ethyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 685886-50-4
7-[2,6-dimethoxy-4-(methoxymethyl)phenyl]-2-ethyl-3-nitropyrazolo[1,5-a]pyridine

: 685885-89-6
7-[2,6-dimethoxy-4-(methoxymethyl)phenyl]-2-ethylpyrazolo[1,5-a]pyridine-3-amine

Guidance literature:: With hydrogen; palladium 10% on activated carbon; In methanol; at 50 ℃; for 13h;

Reference yield:

: 109-04-6
2-bromo-pyridine

: 685885-89-6
7-[2,6-dimethoxy-4-(methoxymethyl)phenyl]-2-ethylpyrazolo[1,5-a]pyridine-3-amine

Guidance literature:: Multi-step reaction with 7 steps

1.1: copper(l) iodide; diethylamine / bis-triphenylphosphine-palladium(II) chloride / 4 h / 20 °C

2.1: dichloromethane / 0.5 h / 0 °C

3.1: potassium tert-butylate / tetrahydrofuran / 0.5 h / 20 °C

4.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -70 - -60 °C

4.2: 2 h / -70 - 20 °C

5.1: sulfuric acid; nitric acid / 0.5 h / 30 °C

6.1: potassium phosphate; triphenylphosphine / palladium diacetate / 1,2-dimethoxyethane / 14 h / Heating / reflux

7.1: hydrogen / palladium 10% on activated carbon / methanol / 13 h / 50 °C

With potassium phosphate; copper(l) iodide; n-butyllithium; sulfuric acid; potassium tert-butylate; hydrogen; nitric acid; diethylamine; triphenylphosphine; bis-triphenylphosphine-palladium(II) chloride; palladium 10% on activated carbon; palladium diacetate; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; hexane; dichloromethane;

Reference yield:

: 475174-65-3
2-ethylpyrazolo[1,5-a]pyridine

: 685885-89-6
7-[2,6-dimethoxy-4-(methoxymethyl)phenyl]-2-ethylpyrazolo[1,5-a]pyridine-3-amine

Guidance literature:: Multi-step reaction with 4 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -70 - -60 °C

1.2: 2 h / -70 - 20 °C

2.1: sulfuric acid; nitric acid / 0.5 h / 30 °C

3.1: potassium phosphate; triphenylphosphine / palladium diacetate / 1,2-dimethoxyethane / 14 h / Heating / reflux

4.1: hydrogen / palladium 10% on activated carbon / methanol / 13 h / 50 °C

With potassium phosphate; n-butyllithium; sulfuric acid; hydrogen; nitric acid; triphenylphosphine; palladium 10% on activated carbon; palladium diacetate; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; hexane;