methyl 6-(4-(3-chloro-4-fluorophenylamino)-7-(2-methoxyethoxy)quinazolin-6-ylamino)-6-oxohexanoate

Base Information

Chemical Name:methyl 6-(4-(3-chloro-4-fluorophenylamino)-7-(2-methoxyethoxy)quinazolin-6-ylamino)-6-oxohexanoate
CAS No.:1012057-61-2
Molecular Formula:C₂₄H₂₆ClFN₄O₅
Molecular Weight:504.946
Hs Code.:

Synonyms:methyl 6-(4-(3-chloro-4-fluorophenylamino)-7-(2-methoxyethoxy)quinazolin-6-ylamino)-6-oxohexanoate

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Chemical Property of methyl 6-(4-(3-chloro-4-fluorophenylamino)-7-(2-methoxyethoxy)quinazolin-6-ylamino)-6-oxohexanoate

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Technology Process of methyl 6-(4-(3-chloro-4-fluorophenylamino)-7-(2-methoxyethoxy)quinazolin-6-ylamino)-6-oxohexanoate

There total 7 articles about methyl 6-(4-(3-chloro-4-fluorophenylamino)-7-(2-methoxyethoxy)quinazolin-6-ylamino)-6-oxohexanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

N⁴-(3-chloro-4-fluorophenyl)-7-(2-methoxyethoxy)quinazoline-4,6-diamine: 402855-01-0
N⁴-(3-chloro-4-fluorophenyl)-7-(2-methoxyethoxy)quinazoline-4,6-diamine

: 35444-44-1
methyl adipoyl chloride

: 1012057-61-2
methyl 6-(4-(3-chloro-4-fluorophenylamino)-7-(2-methoxyethoxy)quinazolin-6-ylamino)-6-oxohexanoate

Guidance literature:: With triethylamine; In dichloromethane; at 0 ℃; for 2h;

Reference yield:

: 53449-14-2
7-chloro-6-nitro-4(3H)-quinazolinone

: 1012057-61-2
methyl 6-(4-(3-chloro-4-fluorophenylamino)-7-(2-methoxyethoxy)quinazolin-6-ylamino)-6-oxohexanoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium

1.2: 24 h / 90 °C

2.1: trichlorophosphate / 5 h / Heating / reflux

3.1: i-Amyl alcohol / Heating / reflux

4.1: hydrogenchloride; water; iron / ethanol / 2 h / Heating / reflux

4.2: pH 11

5.1: triethylamine / dichloromethane / 2 h / 0 °C

With hydrogenchloride; water; sodium; iron; triethylamine; trichlorophosphate; In ethanol; i-Amyl alcohol; dichloromethane;

Reference yield:

: 31374-18-2
7-chloro-3,4-dihydroquinazolin-4-one

: 1012057-61-2
methyl 6-(4-(3-chloro-4-fluorophenylamino)-7-(2-methoxyethoxy)quinazolin-6-ylamino)-6-oxohexanoate

Guidance literature:: Multi-step reaction with 6 steps

1.1: sulfuric acid; nitric acid / 0 - 45 °C

2.1: sodium

2.2: 24 h / 90 °C

3.1: trichlorophosphate / 5 h / Heating / reflux

4.1: i-Amyl alcohol / Heating / reflux

5.1: hydrogenchloride; water; iron / ethanol / 2 h / Heating / reflux

5.2: pH 11

6.1: triethylamine / dichloromethane / 2 h / 0 °C

With hydrogenchloride; sulfuric acid; water; nitric acid; sodium; iron; triethylamine; trichlorophosphate; In ethanol; i-Amyl alcohol; dichloromethane;