methyl 8-(4-(3-chloro-4-fluorophenylamino)-7-(2-methoxyethoxy)quinazolin-6-ylamino)-8-oxooctanoate

Base Information

Chemical Name:methyl 8-(4-(3-chloro-4-fluorophenylamino)-7-(2-methoxyethoxy)quinazolin-6-ylamino)-8-oxooctanoate
CAS No.:1012057-62-3
Molecular Formula:C₂₆H₃₀ClFN₄O₅
Molecular Weight:532.999
Hs Code.:

Synonyms:methyl 8-(4-(3-chloro-4-fluorophenylamino)-7-(2-methoxyethoxy)quinazolin-6-ylamino)-8-oxooctanoate

Suppliers and Price of methyl 8-(4-(3-chloro-4-fluorophenylamino)-7-(2-methoxyethoxy)quinazolin-6-ylamino)-8-oxooctanoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of methyl 8-(4-(3-chloro-4-fluorophenylamino)-7-(2-methoxyethoxy)quinazolin-6-ylamino)-8-oxooctanoate

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of methyl 8-(4-(3-chloro-4-fluorophenylamino)-7-(2-methoxyethoxy)quinazolin-6-ylamino)-8-oxooctanoate

There total 8 articles about methyl 8-(4-(3-chloro-4-fluorophenylamino)-7-(2-methoxyethoxy)quinazolin-6-ylamino)-8-oxooctanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

N⁴-(3-chloro-4-fluorophenyl)-7-(2-methoxyethoxy)quinazoline-4,6-diamine: 402855-01-0
N⁴-(3-chloro-4-fluorophenyl)-7-(2-methoxyethoxy)quinazoline-4,6-diamine

: 41624-92-4
methyl 8-chloro-8-oxooctanoate

: 1012057-62-3
methyl 8-(4-(3-chloro-4-fluorophenylamino)-7-(2-methoxyethoxy)quinazolin-6-ylamino)-8-oxooctanoate

Guidance literature:: With triethylamine; In dichloromethane; at 0 ℃; for 2h;

Reference yield: 88.0%

: 1012057-61-2
methyl 6-(4-(3-chloro-4-fluorophenylamino)-7-(2-methoxyethoxy)quinazolin-6-ylamino)-6-oxohexanoate

: 41624-92-4
methyl 8-chloro-8-oxooctanoate

: 1012057-62-3
methyl 8-(4-(3-chloro-4-fluorophenylamino)-7-(2-methoxyethoxy)quinazolin-6-ylamino)-8-oxooctanoate

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 4h;

Reference yield:

: 53449-14-2
7-chloro-6-nitro-4(3H)-quinazolinone

: 1012057-62-3
methyl 8-(4-(3-chloro-4-fluorophenylamino)-7-(2-methoxyethoxy)quinazolin-6-ylamino)-8-oxooctanoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium

1.2: 24 h / 90 °C

2.1: trichlorophosphate / 5 h / Heating / reflux

3.1: i-Amyl alcohol / Heating / reflux

4.1: hydrogenchloride; water; iron / ethanol / 2 h / Heating / reflux

4.2: pH 11

5.1: triethylamine / dichloromethane / 2 h / 0 °C

With hydrogenchloride; water; sodium; iron; triethylamine; trichlorophosphate; In ethanol; i-Amyl alcohol; dichloromethane;