4-ethyl 3,5-dimethyl 1-(4-methoxyphenyl)-2,6-dimethyl-1,4-dihydropyridine-3,4,5-tricarboxylate

Base Information

• Chemical Name: 4-ethyl 3,5-dimethyl 1-(4-methoxyphenyl)-2,6-dimethyl-1,4-dihydropyridine-3,4,5-tricarboxylate
• CAS No.: 1190383-72-2
• Molecular Formula: C₂₁H₂₅NO₇
• Molecular Weight: 403.432
• Mol file: 1190383-72-2.mol

Synonyms:4-ethyl 3,5-dimethyl 1-(4-methoxyphenyl)-2,6-dimethyl-1,4-dihydropyridine-3,4,5-tricarboxylate

Chemical Property of 4-ethyl 3,5-dimethyl 1-(4-methoxyphenyl)-2,6-dimethyl-1,4-dihydropyridine-3,4,5-tricarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-ethyl 3,5-dimethyl 1-(4-methoxyphenyl)-2,6-dimethyl-1,4-dihydropyridine-3,4,5-tricarboxylate

There total 4 articles about 4-ethyl 3,5-dimethyl 1-(4-methoxyphenyl)-2,6-dimethyl-1,4-dihydropyridine-3,4,5-tricarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

glyoxylic acid ethyl ester (924-44-7) + 4-methoxy-aniline (104-94-9) + acetoacetic acid methyl ester (105-45-3) → 4-ethyl 3,5-dimethyl 1-(4-methoxyphenyl)-2,6-dimethyl-1,4-dihydropyridine-3,4,5-tricarboxylate (1190383-72-2)

Guidance literature:

With montmorillonite K-10; at 20 ℃; Green chemistry;

DOI:10.1016/j.tet.2013.04.006

Reference yield: 85.0%

ethyl (4-methoxyphenylimino)acetate (124156-21-4) + acetoacetic acid methyl ester (105-45-3) → 4-ethyl 3,5-dimethyl 1-(4-methoxyphenyl)-2,6-dimethyl-1,4-dihydropyridine-3,4,5-tricarboxylate (1190383-72-2)

Guidance literature:

With copper(ll) bromide; at 20 ℃; for 18h; Neat (no solvent);

DOI:10.2174/157017809787893082

Reference yield: 78.0%

N-(4-methoxy)phenylglycine ethyl ester (50845-77-7) + acetoacetic acid methyl ester (105-45-3) → 4-ethyl 3,5-dimethyl 1-(4-methoxyphenyl)-2,6-dimethyl-1,4-dihydropyridine-3,4,5-tricarboxylate (1190383-72-2)

Guidance literature:

With chloro-trimethyl-silane; oxygen; tris(p-bromophenylammoniumyl) hexachloroantimonate; In acetonitrile; at 60 ℃; for 4h;

DOI:10.1002/adsc.201300810

upstream raw materials:

3-acetyl-2-(4-methoxyphenylamino)-butanedioic acid ethyl methyl ester

acetoacetic acid methyl ester

ethyl (4-methoxyphenylimino)acetate

glyoxylic acid ethyl ester