(S)-2-amino-N-((1R,2R)-1-cyano-2-(4'-(4-methylpiperazin-1-ylsulfonyl)biphenyl-4-yl)cyclopropyl)-3-cyclopropylpropanamide

Base Information

Chemical Name:(S)-2-amino-N-((1R,2R)-1-cyano-2-(4'-(4-methylpiperazin-1-ylsulfonyl)biphenyl-4-yl)cyclopropyl)-3-cyclopropylpropanamide
CAS No.:1401624-34-7
Molecular Formula:C₂₇H₃₃N₅O₃S
Molecular Weight:507.657
Hs Code.:

Synonyms:(S)-2-amino-N-((1R,2R)-1-cyano-2-(4'-(4-methylpiperazin-1-ylsulfonyl)biphenyl-4-yl)cyclopropyl)-3-cyclopropylpropanamide

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Chemical Property of (S)-2-amino-N-((1R,2R)-1-cyano-2-(4'-(4-methylpiperazin-1-ylsulfonyl)biphenyl-4-yl)cyclopropyl)-3-cyclopropylpropanamide

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Technology Process of (S)-2-amino-N-((1R,2R)-1-cyano-2-(4'-(4-methylpiperazin-1-ylsulfonyl)biphenyl-4-yl)cyclopropyl)-3-cyclopropylpropanamide

There total 6 articles about (S)-2-amino-N-((1R,2R)-1-cyano-2-(4'-(4-methylpiperazin-1-ylsulfonyl)biphenyl-4-yl)cyclopropyl)-3-cyclopropylpropanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

: 1401624-96-1
tert-butyl (S)-1-((1R,2R)-1-cyano-2-(4'-(4-methylpiperazin-1-ylsulfonyl)biphenyl-4-yl)cyclopropylamino)-3-cyclopropyl-1-oxopropan-2-ylcarbamate

: 1401624-34-7
(S)-2-amino-N-((1R,2R)-1-cyano-2-(4'-(4-methylpiperazin-1-ylsulfonyl)biphenyl-4-yl)cyclopropyl)-3-cyclopropylpropanamide

Guidance literature:: tert-butyl (S)-1-((1R,2R)-1-cyano-2-(4'-(4-methylpiperazin-1-ylsulfonyl)biphenyl-4-yl)cyclopropylamino)-3-cyclopropyl-1-oxopropan-2-ylcarbamate; With formic acid; at 20 ℃; for 4h;

With sodium hydrogencarbonate; In water;

Reference yield:

: 89483-06-7,89483-08-9
(2S)-2-[[(tert-butoxy)carbonyl]amino]-3-cyclopropylpropanoic acid

: 1401624-34-7
(S)-2-amino-N-((1R,2R)-1-cyano-2-(4'-(4-methylpiperazin-1-ylsulfonyl)biphenyl-4-yl)cyclopropyl)-3-cyclopropylpropanamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: DMT-MM / dichloromethane / 2 h / 0 °C

2.1: water; lithium hydroxide monohydrate / tetrahydrofuran / 3 h / 20 °C

2.2: pH 4

2.3: pH 8

3.1: chloroformic acid ethyl ester; triethylamine / dichloromethane / 1 h / 0 °C

3.2: 20 °C

4.1: 1,3,5-trichloro-2,4,6-triazine / N,N-dimethyl-formamide / 4 h / 20 °C

5.1: formic acid / 4 h / 20 °C

With formic acid; 1,3,5-trichloro-2,4,6-triazine; lithium hydroxide monohydrate; DMT-MM; water; chloroformic acid ethyl ester; triethylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1401624-92-7
(1R,2R)-methyl 1-((S)-2-(tert-butoxycarbonylamino)-3-cyclopropyl-propanamido)-2-(4'-(4-methylpiperazin-1-ylsulfonyl)biphenyl-4-yl)cyclopropanecarboxylate

: 1401624-34-7
(S)-2-amino-N-((1R,2R)-1-cyano-2-(4'-(4-methylpiperazin-1-ylsulfonyl)biphenyl-4-yl)cyclopropyl)-3-cyclopropylpropanamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: water; lithium hydroxide monohydrate / tetrahydrofuran / 3 h / 20 °C

1.2: pH 4

1.3: pH 8

2.1: chloroformic acid ethyl ester; triethylamine / dichloromethane / 1 h / 0 °C

2.2: 20 °C

3.1: 1,3,5-trichloro-2,4,6-triazine / N,N-dimethyl-formamide / 4 h / 20 °C

4.1: formic acid / 4 h / 20 °C

With formic acid; 1,3,5-trichloro-2,4,6-triazine; lithium hydroxide monohydrate; water; chloroformic acid ethyl ester; triethylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;