tert-butyl (S)-1-((1R,2R)-1-carbamoyl-2-(4'-(4-methylpiperazin-1-yl-sulfonyl)biphenyl-4-yl)cyclopropylamino)-3-cyclopropyl-oxopropan-2-ylcarbamate

Base Information

Chemical Name:tert-butyl (S)-1-((1R,2R)-1-carbamoyl-2-(4'-(4-methylpiperazin-1-yl-sulfonyl)biphenyl-4-yl)cyclopropylamino)-3-cyclopropyl-oxopropan-2-ylcarbamate
CAS No.:1401624-94-9
Molecular Formula:C₃₂H₄₃N₅O₆S
Molecular Weight:625.789
Hs Code.:

tert-butyl (S)-1-((1R,2R)-1-carbamoyl-2-(4'-(4-methylpiperazin-1-yl-sulfonyl)biphenyl-4-yl)cyclopropylamino)-3-cyclopropyl-oxopropan-2-ylcarbamate

Synonyms:tert-butyl (S)-1-((1R,2R)-1-carbamoyl-2-(4'-(4-methylpiperazin-1-yl-sulfonyl)biphenyl-4-yl)cyclopropylamino)-3-cyclopropyl-oxopropan-2-ylcarbamate

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Chemical Property of tert-butyl (S)-1-((1R,2R)-1-carbamoyl-2-(4'-(4-methylpiperazin-1-yl-sulfonyl)biphenyl-4-yl)cyclopropylamino)-3-cyclopropyl-oxopropan-2-ylcarbamate

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Technology Process of tert-butyl (S)-1-((1R,2R)-1-carbamoyl-2-(4'-(4-methylpiperazin-1-yl-sulfonyl)biphenyl-4-yl)cyclopropylamino)-3-cyclopropyl-oxopropan-2-ylcarbamate

There total 4 articles about tert-butyl (S)-1-((1R,2R)-1-carbamoyl-2-(4'-(4-methylpiperazin-1-yl-sulfonyl)biphenyl-4-yl)cyclopropylamino)-3-cyclopropyl-oxopropan-2-ylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₃₂H₄₂N₄O₇S

: 1401624-94-9
tert-butyl (S)-1-((1R,2R)-1-carbamoyl-2-(4'-(4-methylpiperazin-1-yl-sulfonyl)biphenyl-4-yl)cyclopropylamino)-3-cyclopropyl-oxopropan-2-ylcarbamate

Guidance literature:: C₃₂H₄₂N₄O₇S; With chloroformic acid ethyl ester; triethylamine; In dichloromethane; at 0 ℃; for 1h;

With ammonia; In dichloromethane; at 20 ℃;

Reference yield:

: 89483-06-7,89483-08-9
(2S)-2-[[(tert-butoxy)carbonyl]amino]-3-cyclopropylpropanoic acid

: 1401624-94-9
tert-butyl (S)-1-((1R,2R)-1-carbamoyl-2-(4'-(4-methylpiperazin-1-yl-sulfonyl)biphenyl-4-yl)cyclopropylamino)-3-cyclopropyl-oxopropan-2-ylcarbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: DMT-MM / dichloromethane / 2 h / 0 °C

2.1: water; lithium hydroxide monohydrate / tetrahydrofuran / 3 h / 20 °C

2.2: pH 4

2.3: pH 8

3.1: chloroformic acid ethyl ester; triethylamine / dichloromethane / 1 h / 0 °C

3.2: 20 °C

With lithium hydroxide monohydrate; DMT-MM; water; chloroformic acid ethyl ester; triethylamine; In tetrahydrofuran; dichloromethane;

Reference yield:

: methyl 1-amino-2-[4'-(4-methylplperailn-1-yI-sulfonyl)-biphenyl-4-yl]cyclopropanecarboxylate

: 1401624-94-9
tert-butyl (S)-1-((1R,2R)-1-carbamoyl-2-(4'-(4-methylpiperazin-1-yl-sulfonyl)biphenyl-4-yl)cyclopropylamino)-3-cyclopropyl-oxopropan-2-ylcarbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: DMT-MM / dichloromethane / 2 h / 0 °C

2.1: water; lithium hydroxide monohydrate / tetrahydrofuran / 3 h / 20 °C

2.2: pH 4

2.3: pH 8

3.1: chloroformic acid ethyl ester; triethylamine / dichloromethane / 1 h / 0 °C

3.2: 20 °C

With lithium hydroxide monohydrate; DMT-MM; water; chloroformic acid ethyl ester; triethylamine; In tetrahydrofuran; dichloromethane;