(1R,2R)-methyl 1-((S)-2-(tert-butoxycarbonylamino)-3-cyclopropyl-propanamido)-2-(4'-(4-methylpiperazin-1-ylsulfonyl)biphenyl-4-yl)cyclopropanecarboxylate

Base Information

Chemical Name:(1R,2R)-methyl 1-((S)-2-(tert-butoxycarbonylamino)-3-cyclopropyl-propanamido)-2-(4'-(4-methylpiperazin-1-ylsulfonyl)biphenyl-4-yl)cyclopropanecarboxylate
CAS No.:1401624-92-7
Molecular Formula:C₃₃H₄₄N₄O₇S
Molecular Weight:640.801
Hs Code.:

(1R,2R)-methyl 1-((S)-2-(tert-butoxycarbonylamino)-3-cyclopropyl-propanamido)-2-(4'-(4-methylpiperazin-1-ylsulfonyl)biphenyl-4-yl)cyclopropanecarboxylate

Synonyms:(1R,2R)-methyl 1-((S)-2-(tert-butoxycarbonylamino)-3-cyclopropyl-propanamido)-2-(4'-(4-methylpiperazin-1-ylsulfonyl)biphenyl-4-yl)cyclopropanecarboxylate

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Chemical Property of (1R,2R)-methyl 1-((S)-2-(tert-butoxycarbonylamino)-3-cyclopropyl-propanamido)-2-(4'-(4-methylpiperazin-1-ylsulfonyl)biphenyl-4-yl)cyclopropanecarboxylate

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Technology Process of (1R,2R)-methyl 1-((S)-2-(tert-butoxycarbonylamino)-3-cyclopropyl-propanamido)-2-(4'-(4-methylpiperazin-1-ylsulfonyl)biphenyl-4-yl)cyclopropanecarboxylate

There total 1 articles about (1R,2R)-methyl 1-((S)-2-(tert-butoxycarbonylamino)-3-cyclopropyl-propanamido)-2-(4'-(4-methylpiperazin-1-ylsulfonyl)biphenyl-4-yl)cyclopropanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: methyl 1-amino-2-[4'-(4-methylplperailn-1-yI-sulfonyl)-biphenyl-4-yl]cyclopropanecarboxylate

: 89483-06-7,89483-08-9
(2S)-2-[[(tert-butoxy)carbonyl]amino]-3-cyclopropylpropanoic acid

: 1401624-92-7
(1R,2R)-methyl 1-((S)-2-(tert-butoxycarbonylamino)-3-cyclopropyl-propanamido)-2-(4'-(4-methylpiperazin-1-ylsulfonyl)biphenyl-4-yl)cyclopropanecarboxylate

: 1401624-93-8
(1S,2S)-methyl 1-((S)-2-(tert-butoxycarbonylamino)-3-cyclopropyl-propanamido)-2-(4'-(4-methylpiperazin-1-ylsulfonyl)biphenyl-4-yl)cyclopropanecarboxylate

Guidance literature:: With DMT-MM; In dichloromethane; at 0 ℃; for 2h;

Reference yield:

: 1401624-92-7
(1R,2R)-methyl 1-((S)-2-(tert-butoxycarbonylamino)-3-cyclopropyl-propanamido)-2-(4'-(4-methylpiperazin-1-ylsulfonyl)biphenyl-4-yl)cyclopropanecarboxylate

: C₃₂H₄₂N₄O₇S

Guidance literature:: (1R,2R)-methyl 1-((S)-2-(tert-butoxycarbonylamino)-3-cyclopropyl-propanamido)-2-(4'-(4-methylpiperazin-1-ylsulfonyl)biphenyl-4-yl)cyclopropanecarboxylate; With lithium hydroxide monohydrate; water; In tetrahydrofuran; at 20 ℃; for 3h;

With potassium hydrogensulfate; In tetrahydrofuran; water; pH=4;

With triethylamine; In tetrahydrofuran; water; pH=8;

Reference yield:

: 1401624-92-7
(1R,2R)-methyl 1-((S)-2-(tert-butoxycarbonylamino)-3-cyclopropyl-propanamido)-2-(4'-(4-methylpiperazin-1-ylsulfonyl)biphenyl-4-yl)cyclopropanecarboxylate

: 1401624-96-1
tert-butyl (S)-1-((1R,2R)-1-cyano-2-(4'-(4-methylpiperazin-1-ylsulfonyl)biphenyl-4-yl)cyclopropylamino)-3-cyclopropyl-1-oxopropan-2-ylcarbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: water; lithium hydroxide monohydrate / tetrahydrofuran / 3 h / 20 °C

1.2: pH 4

1.3: pH 8

2.1: chloroformic acid ethyl ester; triethylamine / dichloromethane / 1 h / 0 °C

2.2: 20 °C

3.1: 1,3,5-trichloro-2,4,6-triazine / N,N-dimethyl-formamide / 4 h / 20 °C

With 1,3,5-trichloro-2,4,6-triazine; lithium hydroxide monohydrate; water; chloroformic acid ethyl ester; triethylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;