tert-butyl (3R)-4-[2-(3-cyano-4-fluoro-2-methylphenyl)-2-hydroxylethyl]-3-(hydroxymethyl)piperazine-1-carboxylate

Base Information

Chemical Name:tert-butyl (3R)-4-[2-(3-cyano-4-fluoro-2-methylphenyl)-2-hydroxylethyl]-3-(hydroxymethyl)piperazine-1-carboxylate
CAS No.:1426071-27-3
Molecular Formula:C₂₀H₂₈FN₃O₄
Molecular Weight:393.458
Hs Code.:

Synonyms:tert-butyl (3R)-4-[2-(3-cyano-4-fluoro-2-methylphenyl)-2-hydroxylethyl]-3-(hydroxymethyl)piperazine-1-carboxylate

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Chemical Property of tert-butyl (3R)-4-[2-(3-cyano-4-fluoro-2-methylphenyl)-2-hydroxylethyl]-3-(hydroxymethyl)piperazine-1-carboxylate

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Technology Process of tert-butyl (3R)-4-[2-(3-cyano-4-fluoro-2-methylphenyl)-2-hydroxylethyl]-3-(hydroxymethyl)piperazine-1-carboxylate

There total 5 articles about tert-butyl (3R)-4-[2-(3-cyano-4-fluoro-2-methylphenyl)-2-hydroxylethyl]-3-(hydroxymethyl)piperazine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 278788-66-2
(R)-tert-butyl 3-(hydroxymethyl)piperazine-1-carboxylate

: 1255207-46-5
6-fluoro-2-methyl-3-(oxiran-2-yl)benzonitrile

: 1426071-27-3
tert-butyl (3R)-4-[2-(3-cyano-4-fluoro-2-methylphenyl)-2-hydroxylethyl]-3-(hydroxymethyl)piperazine-1-carboxylate

Guidance literature:: In ethanol; at 150 ℃; for 1h; Microwave irradiation;

Reference yield:

: 883502-14-5
1-fluoro-2-iodo-3-methylbenzene

: 1426071-27-3
tert-butyl (3R)-4-[2-(3-cyano-4-fluoro-2-methylphenyl)-2-hydroxylethyl]-3-(hydroxymethyl)piperazine-1-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl acetamide / 16 h / 80 °C / Inert atmosphere

2: trifluorormethanesulfonic acid; N-Bromosuccinimide / 1 h / 0 - 20 °C

3: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; triethylamine / ethanol / 4 h / Inert atmosphere; Reflux

4: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 72 h / 0 - 20 °C

5: ethanol / 1 h / 150 °C / Microwave irradiation

With N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; trifluorormethanesulfonic acid; triethylamine; 3-chloro-benzenecarboperoxoic acid; In ethanol; dichloromethane; N,N-dimethyl acetamide;

Reference yield:

: 1255207-47-6
3-bromo-6-fluoro-2-methyl-benzonitrile

: 1426071-27-3
tert-butyl (3R)-4-[2-(3-cyano-4-fluoro-2-methylphenyl)-2-hydroxylethyl]-3-(hydroxymethyl)piperazine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; triethylamine / ethanol / 4 h / Inert atmosphere; Reflux

2: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 72 h / 0 - 20 °C

3: ethanol / 1 h / 150 °C / Microwave irradiation

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; triethylamine; 3-chloro-benzenecarboperoxoic acid; In ethanol; dichloromethane;