[(S)-1-((1R,2S)-2-Diethylcarbamoyl-2-phenyl-cyclopropyl)-3-phenylselanyl-propyl]-carbamic acid tert-butyl ester

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Chemical Name:[(S)-1-((1R,2S)-2-Diethylcarbamoyl-2-phenyl-cyclopropyl)-3-phenylselanyl-propyl]-carbamic acid tert-butyl ester
CAS No.:171889-32-0
Molecular Formula:C₂₈H₃₈N₂O₃Se
Molecular Weight:529.581
Hs Code.:

Synonyms:[(S)-1-((1R,2S)-2-Diethylcarbamoyl-2-phenyl-cyclopropyl)-3-phenylselanyl-propyl]-carbamic acid tert-butyl ester

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Chemical Property of [(S)-1-((1R,2S)-2-Diethylcarbamoyl-2-phenyl-cyclopropyl)-3-phenylselanyl-propyl]-carbamic acid tert-butyl ester

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Technology Process of [(S)-1-((1R,2S)-2-Diethylcarbamoyl-2-phenyl-cyclopropyl)-3-phenylselanyl-propyl]-carbamic acid tert-butyl ester

There total 10 articles about [(S)-1-((1R,2S)-2-Diethylcarbamoyl-2-phenyl-cyclopropyl)-3-phenylselanyl-propyl]-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 171889-31-9
(1S,2R)-2-((S)-1-Amino-3-phenylselanyl-propyl)-1-phenyl-cyclopropanecarboxylic acid diethylamide

: 171889-32-0
[(S)-1-((1R,2S)-2-Diethylcarbamoyl-2-phenyl-cyclopropyl)-3-phenylselanyl-propyl]-carbamic acid tert-butyl ester

Guidance literature:: In dichloromethane; for 5h; Ambient temperature;
DOI:10.1021/jm960495w

Reference yield:

: 23974-72-3
sodium phenylselenide

: 171889-32-0
[(S)-1-((1R,2S)-2-Diethylcarbamoyl-2-phenyl-cyclopropyl)-3-phenylselanyl-propyl]-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 85 percent / ethanol / 15 h / Ambient temperature

2: pyridine / 1 h / Ambient temperature

3: 28percent aq. NH₄OH / 12 h / Ambient temperature

4: 92 percent / CH₂Cl₂ / 5 h / Ambient temperature

With pyridine; ammonium hydroxide; In ethanol; dichloromethane;
DOI:10.1021/jm960495w

Reference yield:

: 171889-34-2
(1S,2R)-2-((S)-1,3-Dihydroxy-propyl)-1-phenyl-cyclopropanecarboxylic acid diethylamide

: 171889-32-0
[(S)-1-((1R,2S)-2-Diethylcarbamoyl-2-phenyl-cyclopropyl)-3-phenylselanyl-propyl]-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: 88 percent / pyridine / 1.5 h / 0 °C

2: 91 percent / NaN₃, Ph₃P, CBr₄ / dimethylformamide / 3 h / Ambient temperature

3: 99 percent / MeONa, MeOH / 15 h / Ambient temperature

4: 99 percent / Et₃N, DMAP / CH₂Cl₂ / 15 h / Ambient temperature

5: 85 percent / ethanol / 15 h / Ambient temperature

6: pyridine / 1 h / Ambient temperature

7: 28percent aq. NH₄OH / 12 h / Ambient temperature

8: 92 percent / CH₂Cl₂ / 5 h / Ambient temperature

With pyridine; methanol; dmap; ammonium hydroxide; sodium azide; carbon tetrabromide; sodium methylate; triethylamine; triphenylphosphine; In ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm960495w