4-(4-(5-(4-chlorophenyl)-2-(4-methoxyphenyl)-1H-pyrrol-3-yl)-3-p-tolyl-1H-pyrazol-1-yl)benzenesulfonamide

Base Information

• Chemical Name: 4-(4-(5-(4-chlorophenyl)-2-(4-methoxyphenyl)-1H-pyrrol-3-yl)-3-p-tolyl-1H-pyrazol-1-yl)benzenesulfonamide
• CAS No.: 1443022-06-7
• Molecular Formula: C₃₃H₂₇ClN₄O₃S
• Molecular Weight: 595.121
• Mol file: 1443022-06-7.mol

Synonyms:4-(4-(5-(4-chlorophenyl)-2-(4-methoxyphenyl)-1H-pyrrol-3-yl)-3-p-tolyl-1H-pyrazol-1-yl)benzenesulfonamide

Chemical Property of 4-(4-(5-(4-chlorophenyl)-2-(4-methoxyphenyl)-1H-pyrrol-3-yl)-3-p-tolyl-1H-pyrazol-1-yl)benzenesulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(4-(5-(4-chlorophenyl)-2-(4-methoxyphenyl)-1H-pyrrol-3-yl)-3-p-tolyl-1H-pyrazol-1-yl)benzenesulfonamide

There total 7 articles about 4-(4-(5-(4-chlorophenyl)-2-(4-methoxyphenyl)-1H-pyrrol-3-yl)-3-p-tolyl-1H-pyrazol-1-yl)benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

4-(4-(4-(4-chlorophenyl)-1-(4-methoxyphenyl)-1,4-dioxobutan-2-yl)-3-p-tolyl-1H-pyrazol-1-yl)benzenesulfonamide (1443021-98-4) → 4-(4-(5-(4-chlorophenyl)-2-(4-methoxyphenyl)-1H-pyrrol-3-yl)-3-p-tolyl-1H-pyrazol-1-yl)benzenesulfonamide (1443022-06-7)

Guidance literature:

With ammonium acetate; acetic acid; at 110 ℃; for 20h;

DOI:10.1016/j.ejmech.2013.03.005

Reference yield:

4-hydrazinobenzene-1-sulfonamide hydrochloride (17852-52-7,27918-19-0) → 4-(4-(5-(4-chlorophenyl)-2-(4-methoxyphenyl)-1H-pyrrol-3-yl)-3-p-tolyl-1H-pyrazol-1-yl)benzenesulfonamide (1443022-06-7)

Guidance literature:

Multi-step reaction with 6 steps

1: acetic acid / ethanol / 24 h / 20 °C

2: trichlorophosphate / Reflux

3: sodium hydroxide; methanol / tetrahydrofuran / 20 °C

4: sodium hydroxide / ethanol; water / 24 h / 20 °C

5: potassium cyanide / N,N-dimethyl-formamide / 4 h / 30 - 35 °C

6: acetic acid; ammonium acetate / 20 h / 110 °C

With methanol; potassium cyanide; ammonium acetate; acetic acid; sodium hydroxide; trichlorophosphate; In tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide; 4: |Claisen-Schmidt Condensation / 6: |Paal-Knorr Pyrrole Synthesis;

DOI:10.1016/j.ejmech.2013.03.005

Reference yield:

4-[2-[1-(4-methylphenyl)ethylidene]hydrazinyl]benzenesulfonamide (1061214-06-9) → 4-(4-(5-(4-chlorophenyl)-2-(4-methoxyphenyl)-1H-pyrrol-3-yl)-3-p-tolyl-1H-pyrazol-1-yl)benzenesulfonamide (1443022-06-7)

Guidance literature:

Multi-step reaction with 5 steps

1: trichlorophosphate / Reflux

2: sodium hydroxide; methanol / tetrahydrofuran / 20 °C

3: sodium hydroxide / ethanol; water / 24 h / 20 °C

4: potassium cyanide / N,N-dimethyl-formamide / 4 h / 30 - 35 °C

5: acetic acid; ammonium acetate / 20 h / 110 °C

With methanol; potassium cyanide; ammonium acetate; acetic acid; sodium hydroxide; trichlorophosphate; In tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide; 3: |Claisen-Schmidt Condensation / 5: |Paal-Knorr Pyrrole Synthesis;

DOI:10.1016/j.ejmech.2013.03.005

upstream raw materials:

4-hydrazinobenzene-1-sulfonamide hydrochloride

4-[2-[1-(4-methylphenyl)ethylidene]hydrazinyl]benzenesulfonamide

C₂₀H₂₀N₄O₃S

4-(4-formyl-3-(p-tolyl)-1Hpyrazol-1-yl)benzenesulfonamide