4-(phenylthio)-6-(E-1-propenyl)-1-(4-toluenesulfonyl)-1,2,5,6-tetrahydro-2-pyridinone

Base Information

Chemical Name:4-(phenylthio)-6-(E-1-propenyl)-1-(4-toluenesulfonyl)-1,2,5,6-tetrahydro-2-pyridinone
CAS No.:1415683-60-1
Molecular Formula:C₂₁H₂₁NO₃S₂
Molecular Weight:399.535
Hs Code.:

Synonyms:4-(phenylthio)-6-(E-1-propenyl)-1-(4-toluenesulfonyl)-1,2,5,6-tetrahydro-2-pyridinone

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Chemical Property of 4-(phenylthio)-6-(E-1-propenyl)-1-(4-toluenesulfonyl)-1,2,5,6-tetrahydro-2-pyridinone

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Technology Process of 4-(phenylthio)-6-(E-1-propenyl)-1-(4-toluenesulfonyl)-1,2,5,6-tetrahydro-2-pyridinone

There total 1 articles about 4-(phenylthio)-6-(E-1-propenyl)-1-(4-toluenesulfonyl)-1,2,5,6-tetrahydro-2-pyridinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 6213-94-1
trimethylsiloxyethene

: 597556-89-3
6-allyl-4-(phenylthio)-1-(4-toluenesulfonyl)-1,2,5,6-tetrahydropyridin-2-one

: 1415683-60-1
4-(phenylthio)-6-(E-1-propenyl)-1-(4-toluenesulfonyl)-1,2,5,6-tetrahydro-2-pyridinone

Guidance literature:: With Grubbs catalyst first generation; In toluene; for 10h; Reflux;
DOI:10.1016/j.tet.2012.10.026

Reference yield: 92.0%

: 1415683-60-1
4-(phenylthio)-6-(E-1-propenyl)-1-(4-toluenesulfonyl)-1,2,5,6-tetrahydro-2-pyridinone

: 1415683-61-2
4-(phenylthio)-6-(E-1-propenyl)-1,2,5,6-tetrahydro-2-pyridinone

Guidance literature:: With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; In toluene; for 2h; Reflux;
DOI:10.1016/j.tet.2012.10.026

Reference yield:

: 1415683-60-1
4-(phenylthio)-6-(E-1-propenyl)-1-(4-toluenesulfonyl)-1,2,5,6-tetrahydro-2-pyridinone

: cis-5-methyl-7-(phenylthio)-3,5,8,8a-tetrahydro-indolizidine

Guidance literature:: Multi-step reaction with 4 steps

1.1: tri-n-butyl-tin hydride; 2,2'-azobis(isobutyronitrile) / toluene / 2 h / Reflux

2.1: n-butyllithium; N,N,N,N,N,N-hexamethylphosphoric triamide / hexane; tetrahydrofuran / -78 °C

2.2: -78 - 20 °C

3.1: Grubbs catalyst first generation / dichloromethane / 24 h / 20 °C

4.1: tetrahydrofuran / 2.5 h / 60 °C

4.2: 0 °C

4.3: 3 h / 0 °C

With Grubbs catalyst first generation; N,N,N,N,N,N-hexamethylphosphoric triamide; n-butyllithium; 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; In tetrahydrofuran; hexane; dichloromethane; toluene;
DOI:10.1016/j.tet.2012.10.026