Technology Process of (2-chloro-6-fluorophenyl)(1H-pyrrolo[3,2-c]pyridin-1-yl)methanone
There total 5 articles about (2-chloro-6-fluorophenyl)(1H-pyrrolo[3,2-c]pyridin-1-yl)methanone which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
2-chloro-6-fluorobenzoic acid;
With
oxalyl dichloride;
N,N-dimethyl-formamide;
In
dichloromethane;
at 0 - 20 ℃;
for 1.75h;
5-azaindole;
With
triethylamine;
In
dichloromethane;
at 20 ℃;
for 20h;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: dihydrogen peroxide / acetic acid / 70 °C / Cooling with ice
2.1: nitric acid / sulfuric acid / 2 h / 0 - 100 °C
3.1: dimethyl amine / N,N-dimethyl-formamide / 15 h / 90 °C
4.1: hydrogen / palladium 10% on activated carbon / methanol / 2 h
5.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 1.75 h / 0 - 20 °C
5.2: 20 h / 20 °C
With
oxalyl dichloride; hydrogen; dihydrogen peroxide; nitric acid; dimethyl amine;
sulfuric acid; palladium 10% on activated carbon; N,N-dimethyl-formamide;
In
methanol; dichloromethane; acetic acid; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: nitric acid / sulfuric acid / 2 h / 0 - 100 °C
2.1: dimethyl amine / N,N-dimethyl-formamide / 15 h / 90 °C
3.1: hydrogen / palladium 10% on activated carbon / methanol / 2 h
4.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 1.75 h / 0 - 20 °C
4.2: 20 h / 20 °C
With
oxalyl dichloride; hydrogen; nitric acid; dimethyl amine;
sulfuric acid; palladium 10% on activated carbon; N,N-dimethyl-formamide;
In
methanol; dichloromethane; N,N-dimethyl-formamide;
