N,O-bis(phenoxycarbonyl)-N-<4-<5-(4-fluorophenoxy)-2-furyl>-3-butyn-2-yl>hydroxylamine

Base Information

Chemical Name:N,O-bis(phenoxycarbonyl)-N-<4-<5-(4-fluorophenoxy)-2-furyl>-3-butyn-2-yl>hydroxylamine
CAS No.:141598-93-8
Molecular Formula:C₂₈H₂₀FNO₇
Molecular Weight:501.468
Hs Code.:

Synonyms:N,O-bis(phenoxycarbonyl)-N-<4-<5-(4-fluorophenoxy)-2-furyl>-3-butyn-2-yl>hydroxylamine

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Chemical Property of N,O-bis(phenoxycarbonyl)-N-<4-<5-(4-fluorophenoxy)-2-furyl>-3-butyn-2-yl>hydroxylamine

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Technology Process of N,O-bis(phenoxycarbonyl)-N-<4-<5-(4-fluorophenoxy)-2-furyl>-3-butyn-2-yl>hydroxylamine

There total 7 articles about N,O-bis(phenoxycarbonyl)-N-<4-<5-(4-fluorophenoxy)-2-furyl>-3-butyn-2-yl>hydroxylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 141580-65-6
N,O-Bis(phenoxycarbonyl)hydroxylamine

: 141580-64-5
4-<5-(4-fluorophenoxy)-2-furyl>-3-butyn-2-ol

: 141598-93-8
N,O-bis(phenoxycarbonyl)-N-<4-<5-(4-fluorophenoxy)-2-furyl>-3-butyn-2-yl>hydroxylamine

Guidance literature:: With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; for 0.5h; Ambient temperature;
DOI:10.1021/jm00024a004

Reference yield:

: 698-63-5
5-nitrofurane-2-carboxaldehyde

: 141598-93-8
N,O-bis(phenoxycarbonyl)-N-<4-<5-(4-fluorophenoxy)-2-furyl>-3-butyn-2-yl>hydroxylamine

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) sodium hydride / 1.) THF, 2.) DMF, 0.5h

2: 1.) zinc, triphenylphosphine / 1.) CH₂Cl₂, overnight, 2.) CH₂Cl₂, RT, 2 h

3: 50 percent / n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C

4: 1.) lithium diisopropylamide / 1.) THF, -5 deg C, 0.5 h, 2.) THF, from -5 deg C to RT

5: 53 percent / triphenylphosphine, diisopropyl azodicarboxylate / tetrahydrofuran / 0.5 h / Ambient temperature

With n-butyllithium; di-isopropyl azodicarboxylate; sodium hydride; triphenylphosphine; zinc; lithium diisopropyl amide; In tetrahydrofuran; hexane;
DOI:10.1021/jm00024a004

Reference yield:

: 33342-17-5
5-(4'-fluorophenyl)furan-2-carbaldehyde

: 141598-93-8
N,O-bis(phenoxycarbonyl)-N-<4-<5-(4-fluorophenoxy)-2-furyl>-3-butyn-2-yl>hydroxylamine

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) zinc, triphenylphosphine / 1.) CH₂Cl₂, overnight, 2.) CH₂Cl₂, RT, 2 h

2: 50 percent / n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C

3: 1.) lithium diisopropylamide / 1.) THF, -5 deg C, 0.5 h, 2.) THF, from -5 deg C to RT

4: 53 percent / triphenylphosphine, diisopropyl azodicarboxylate / tetrahydrofuran / 0.5 h / Ambient temperature

With n-butyllithium; di-isopropyl azodicarboxylate; triphenylphosphine; zinc; lithium diisopropyl amide; In tetrahydrofuran; hexane;
DOI:10.1021/jm00024a004