3-[3-Bromo-5-(2,6-dibromo-4-{2-(2-{3-bromo-5-[2,6-dibromo-4-(2-tert-butoxycarbonylamino-ethyl)-phenoxy]-4-hydroxy-phenyl}-ethylcarbamoyl)-2-[(E)-hydroxyimino]-ethyl}-phenoxy)-4-hydroxy-phenyl]-2-[(Z)-hydroxyimino]-propionic acid

Base Information

• Chemical Name: 3-[3-Bromo-5-(2,6-dibromo-4-{2-(2-{3-bromo-5-[2,6-dibromo-4-(2-tert-butoxycarbonylamino-ethyl)-phenoxy]-4-hydroxy-phenyl}-ethylcarbamoyl)-2-[(E)-hydroxyimino]-ethyl}-phenoxy)-4-hydroxy-phenyl]-2-[(Z)-hydroxyimino]-propionic acid
• CAS No.: 210880-84-5
• Molecular Formula: C₃₉H₃₆Br₆N₄O₁₁
• Molecular Weight: 1216.16
• Mol file: 210880-84-5.mol

Synonyms:3-[3-Bromo-5-(2,6-dibromo-4-{2-(2-{3-bromo-5-[2,6-dibromo-4-(2-tert-butoxycarbonylamino-ethyl)-phenoxy]-4-hydroxy-phenyl}-ethylcarbamoyl)-2-[(E)-hydroxyimino]-ethyl}-phenoxy)-4-hydroxy-phenyl]-2-[(Z)-hydroxyimino]-propionic acid

Chemical Property of 3-[3-Bromo-5-(2,6-dibromo-4-{2-(2-{3-bromo-5-[2,6-dibromo-4-(2-tert-butoxycarbonylamino-ethyl)-phenoxy]-4-hydroxy-phenyl}-ethylcarbamoyl)-2-[(E)-hydroxyimino]-ethyl}-phenoxy)-4-hydroxy-phenyl]-2-[(Z)-hydroxyimino]-propionic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-[3-Bromo-5-(2,6-dibromo-4-{2-(2-{3-bromo-5-[2,6-dibromo-4-(2-tert-butoxycarbonylamino-ethyl)-phenoxy]-4-hydroxy-phenyl}-ethylcarbamoyl)-2-[(E)-hydroxyimino]-ethyl}-phenoxy)-4-hydroxy-phenyl]-2-[(Z)-hydroxyimino]-propionic acid

There total 6 articles about 3-[3-Bromo-5-(2,6-dibromo-4-{2-(2-{3-bromo-5-[2,6-dibromo-4-(2-tert-butoxycarbonylamino-ethyl)-phenoxy]-4-hydroxy-phenyl}-ethylcarbamoyl)-2-[(E)-hydroxyimino]-ethyl}-phenoxy)-4-hydroxy-phenyl]-2-[(Z)-hydroxyimino]-propionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

(2-{3,5-Dibromo-4-[3-bromo-5-(2-{3-(3,5-dibromo-4-{9-bromo-3-[(Z)-hydroxyimino]-2,8-dioxo-1-oxa-spiro[4.5]deca-6,9-dien-7-yloxy}-phenyl)-2-[(E)-hydroxyimino]-propionylamino}-ethyl)-2-hydroxy-phenoxy]-phenyl}-ethyl)-carbamic acid tert-butyl ester (210880-83-4) → 3-[3-Bromo-5-(2,6-dibromo-4-{2-(2-{3-bromo-5-[2,6-dibromo-4-(2-tert-butoxycarbonylamino-ethyl)-phenoxy]-4-hydroxy-phenyl}-ethylcarbamoyl)-2-[(E)-hydroxyimino]-ethyl}-phenoxy)-4-hydroxy-phenyl]-2-[(Z)-hydroxyimino]-propionic acid (210880-84-5)

Guidance literature:

With sodium hydroxide; sodium hydrogensulfite; In water; acetonitrile; at 24 ℃; for 0.166667h; pH 8.0;

DOI:10.1021/jo9721204

Reference yield:

3-(3,5-dibromo-4-hydroxyphenyl)-2-(hydroxyimino)propionic acid (58511-69-6) → 3-[3-Bromo-5-(2,6-dibromo-4-{2-(2-{3-bromo-5-[2,6-dibromo-4-(2-tert-butoxycarbonylamino-ethyl)-phenoxy]-4-hydroxy-phenyl}-ethylcarbamoyl)-2-[(E)-hydroxyimino]-ethyl}-phenoxy)-4-hydroxy-phenyl]-2-[(Z)-hydroxyimino]-propionic acid (210880-84-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 46 percent / H₂O₂, soybean peroxidase / acetonitrile; H₂O / 0.17 h / 24 °C

2: 72 percent / 1-hydroxybenzotriazole, DCC / dioxane; dimethylformamide; CH₂Cl₂ / 24 h / 24 °C

3: 99 percent / NaOH, NaHSO₃ / acetonitrile; H₂O / 0.17 h / 24 °C / pH 8.0

With sodium hydroxide; dihydrogen peroxide; benzotriazol-1-ol; sodium hydrogensulfite; dicyclohexyl-carbodiimide; soybean peroxidase; In 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;

DOI:10.1021/jo9721204

Reference yield:

N-(tert-butoxycarbonyl)-3,5-dibromo-4-hydroxy-β-phenethylamine (210880-88-9) → 3-[3-Bromo-5-(2,6-dibromo-4-{2-(2-{3-bromo-5-[2,6-dibromo-4-(2-tert-butoxycarbonylamino-ethyl)-phenoxy]-4-hydroxy-phenyl}-ethylcarbamoyl)-2-[(E)-hydroxyimino]-ethyl}-phenoxy)-4-hydroxy-phenyl]-2-[(Z)-hydroxyimino]-propionic acid (210880-84-5)

Guidance literature:

Multi-step reaction with 4 steps

1: 53 percent / H₂O₂, soybean peroxidase / acetonitrile / 0.33 h / 24 °C / pH 5.0

2: 98 percent / CrCl₂ / methanol; CH₂Cl₂ / 0.5 h / 24 °C

3: 72 percent / 1-hydroxybenzotriazole, DCC / dioxane; dimethylformamide; CH₂Cl₂ / 24 h / 24 °C

4: 99 percent / NaOH, NaHSO₃ / acetonitrile; H₂O / 0.17 h / 24 °C / pH 8.0

With chromium dichloride; sodium hydroxide; dihydrogen peroxide; benzotriazol-1-ol; sodium hydrogensulfite; dicyclohexyl-carbodiimide; soybean peroxidase; In 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;

DOI:10.1021/jo9721204

upstream raw materials:

(2-{3,5-Dibromo-4-[3-bromo-5-(2-{3-(3,5-dibromo-4-{9-bromo-3-[(Z)-hydroxyimino]-2,8-dioxo-1-oxa-spiro[4.5]deca-6,9-dien-7-yloxy}-phenyl)-2-[(E)-hydroxyimino]-propionylamino}-ethyl)-2-hydroxy-phenoxy]-phenyl}-ethyl)-carbamic acid tert-butyl ester

3-(3,5-dibromo-4-hydroxyphenyl)-2-(hydroxyimino)propionic acid

N-(tert-butoxycarbonyl)-3,5-dibromo-4-hydroxy-β-phenethylamine

tert-butyl (2-{4-[5-(2-aminoethyl)-3-bromo-2-hydroxyphenoxy]-3,5-dibromophenyl}ethyl)carbamate

Downstream raw materials:

3-[3-(4-{2-(2-{3-[4-(2-Amino-ethyl)-2,6-dibromo-phenoxy]-5-bromo-4-hydroxy-phenyl}-ethylcarbamoyl)-2-[(E)-hydroxyimino]-ethyl}-2,6-dibromo-phenoxy)-5-bromo-4-hydroxy-phenyl]-2-[(Z)-hydroxyimino]-propionic acid