3-(4-(4-cyano-2-methylphenyl)-5-(4-methoxyphenyl)thiophen-3-yl)propanoic acid

Base Information

Chemical Name:3-(4-(4-cyano-2-methylphenyl)-5-(4-methoxyphenyl)thiophen-3-yl)propanoic acid
CAS No.:1312099-57-2
Molecular Formula:C₂₂H₁₉NO₃S
Molecular Weight:377.464
Hs Code.:

Synonyms:3-(4-(4-cyano-2-methylphenyl)-5-(4-methoxyphenyl)thiophen-3-yl)propanoic acid

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Chemical Property of 3-(4-(4-cyano-2-methylphenyl)-5-(4-methoxyphenyl)thiophen-3-yl)propanoic acid

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Technology Process of 3-(4-(4-cyano-2-methylphenyl)-5-(4-methoxyphenyl)thiophen-3-yl)propanoic acid

There total 5 articles about 3-(4-(4-cyano-2-methylphenyl)-5-(4-methoxyphenyl)thiophen-3-yl)propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 1312099-55-0
ethyl 3-(5-bromo-4-(4-cyano-2-methylphenyl)thiophen-3-yl)propanoate

: 5720-07-0
4-methoxyphenylboronic acid

: 1312099-57-2
3-(4-(4-cyano-2-methylphenyl)-5-(4-methoxyphenyl)thiophen-3-yl)propanoic acid

Guidance literature:: With sodium carbonate; bis-triphenylphosphine-palladium(II) chloride; In 1,4-dioxane; water; at 100 ℃; Inert atmosphere;

Reference yield:

: 848953-05-9
3-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile

: 1312099-57-2
3-(4-(4-cyano-2-methylphenyl)-5-(4-methoxyphenyl)thiophen-3-yl)propanoic acid

Guidance literature:: Multi-step reaction with 5 steps

1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene; ethanol; water / 80 °C / Inert atmosphere

2: triphenylphosphine; palladium diacetate / N,N-dimethyl-formamide / 150 °C / Inert atmosphere

3: hydrogen / palladium 10% on activated carbon / ethanol / 20 °C / 760.05 Torr

4: N-Bromosuccinimide / N,N-dimethyl-formamide / 100 °C

5: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane; water / 100 °C / Inert atmosphere

With N-Bromosuccinimide; hydrogen; sodium carbonate; bis-triphenylphosphine-palladium(II) chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; palladium diacetate; triphenylphosphine; In 1,4-dioxane; ethanol; water; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1312099-47-0
4-(4-bromothiophen-3-yl)-3-methylbenzonitrile

: 1312099-57-2
3-(4-(4-cyano-2-methylphenyl)-5-(4-methoxyphenyl)thiophen-3-yl)propanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1: triphenylphosphine; palladium diacetate / N,N-dimethyl-formamide / 150 °C / Inert atmosphere

2: hydrogen / palladium 10% on activated carbon / ethanol / 20 °C / 760.05 Torr

3: N-Bromosuccinimide / N,N-dimethyl-formamide / 100 °C

4: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane; water / 100 °C / Inert atmosphere

With N-Bromosuccinimide; hydrogen; sodium carbonate; bis-triphenylphosphine-palladium(II) chloride; palladium 10% on activated carbon; palladium diacetate; triphenylphosphine; In 1,4-dioxane; ethanol; water; N,N-dimethyl-formamide;