3-(4-(4-carbamoyl-2-methylphenyl)-5-(4-methoxyphenyl)thiophen-3-yl)propanoic acid

Base Information

Chemical Name:3-(4-(4-carbamoyl-2-methylphenyl)-5-(4-methoxyphenyl)thiophen-3-yl)propanoic acid
CAS No.:1353572-39-0
Molecular Formula:C₂₂H₂₁NO₄S
Molecular Weight:395.479
Hs Code.:

Synonyms:3-(4-(4-carbamoyl-2-methylphenyl)-5-(4-methoxyphenyl)thiophen-3-yl)propanoic acid

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Chemical Property of 3-(4-(4-carbamoyl-2-methylphenyl)-5-(4-methoxyphenyl)thiophen-3-yl)propanoic acid

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Technology Process of 3-(4-(4-carbamoyl-2-methylphenyl)-5-(4-methoxyphenyl)thiophen-3-yl)propanoic acid

There total 6 articles about 3-(4-(4-carbamoyl-2-methylphenyl)-5-(4-methoxyphenyl)thiophen-3-yl)propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 1312099-57-2
3-(4-(4-cyano-2-methylphenyl)-5-(4-methoxyphenyl)thiophen-3-yl)propanoic acid

: 1353572-39-0
3-(4-(4-carbamoyl-2-methylphenyl)-5-(4-methoxyphenyl)thiophen-3-yl)propanoic acid

Guidance literature:: With dihydrogen peroxide; sodium hydroxide; In dimethyl sulfoxide; at 20 ℃; for 2h;

Reference yield:

: 848953-05-9
3-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile

: 1353572-39-0
3-(4-(4-carbamoyl-2-methylphenyl)-5-(4-methoxyphenyl)thiophen-3-yl)propanoic acid

Guidance literature:: Multi-step reaction with 6 steps

1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene; ethanol; water / 80 °C / Inert atmosphere

2: triphenylphosphine; palladium diacetate / N,N-dimethyl-formamide / 150 °C / Inert atmosphere

3: hydrogen / palladium 10% on activated carbon / ethanol / 20 °C / 760.05 Torr

4: N-Bromosuccinimide / N,N-dimethyl-formamide / 100 °C

5: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane; water / 100 °C / Inert atmosphere

6: sodium hydroxide; dihydrogen peroxide / dimethyl sulfoxide / 2 h / 20 °C

With N-Bromosuccinimide; hydrogen; dihydrogen peroxide; sodium carbonate; sodium hydroxide; bis-triphenylphosphine-palladium(II) chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; palladium diacetate; triphenylphosphine; In 1,4-dioxane; ethanol; water; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1312099-47-0
4-(4-bromothiophen-3-yl)-3-methylbenzonitrile

: 1353572-39-0
3-(4-(4-carbamoyl-2-methylphenyl)-5-(4-methoxyphenyl)thiophen-3-yl)propanoic acid

Guidance literature:: Multi-step reaction with 5 steps

1: triphenylphosphine; palladium diacetate / N,N-dimethyl-formamide / 150 °C / Inert atmosphere

2: hydrogen / palladium 10% on activated carbon / ethanol / 20 °C / 760.05 Torr

3: N-Bromosuccinimide / N,N-dimethyl-formamide / 100 °C

4: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane; water / 100 °C / Inert atmosphere

5: sodium hydroxide; dihydrogen peroxide / dimethyl sulfoxide / 2 h / 20 °C

With N-Bromosuccinimide; hydrogen; dihydrogen peroxide; sodium carbonate; sodium hydroxide; bis-triphenylphosphine-palladium(II) chloride; palladium 10% on activated carbon; palladium diacetate; triphenylphosphine; In 1,4-dioxane; ethanol; water; dimethyl sulfoxide; N,N-dimethyl-formamide;