tert-butyl 2-bromo-4-methoxyphenethylcarbamate

Base Information

Chemical Name:tert-butyl 2-bromo-4-methoxyphenethylcarbamate
CAS No.:1273546-88-5
Molecular Formula:C₁₄H₂₀BrNO₃
Molecular Weight:330.222
Hs Code.:

Synonyms:tert-butyl 2-bromo-4-methoxyphenethylcarbamate

Suppliers and Price of tert-butyl 2-bromo-4-methoxyphenethylcarbamate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of tert-butyl 2-bromo-4-methoxyphenethylcarbamate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of tert-butyl 2-bromo-4-methoxyphenethylcarbamate

There total 9 articles about tert-butyl 2-bromo-4-methoxyphenethylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 466639-53-2
3-bromo-4-iodoanisole

: 97308-23-1
N-(tert-butoxycarbonyl)aziridine

: 1273546-88-5
tert-butyl 2-bromo-4-methoxyphenethylcarbamate

Guidance literature:: 3-bromo-4-iodoanisole; With isopropylmagnesium chloride; In diethyl ether; toluene; at -40 ℃; for 1h;

With copper(I) bromide dimethylsulfide complex; In diethyl ether; toluene; at -40 ℃; for 0.25h;

N-(tert-butoxycarbonyl)aziridine; In diethyl ether; toluene; at -40 - 0 ℃; for 0.583333h;
DOI:10.1021/ol400597f

Reference yield: 58.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 66916-98-1
2-(2-bromo-4-methoxyphenyl)acetonitrile

: 1273546-88-5
tert-butyl 2-bromo-4-methoxyphenethylcarbamate

Guidance literature:: di-tert-butyl dicarbonate; 2-(2-bromo-4-methoxyphenyl)acetonitrile; With sodium tetrahydroborate; nickel(II) chloride hexahydrate; In methanol; at 0 - 20 ℃; for 1.5h;

With diethylamine; In methanol; for 0.5h;
DOI:10.1021/jo102452d

Reference yield:

: 100-02-7,78813-13-5,89830-32-0
4-nitro-phenol

: 1273546-88-5
tert-butyl 2-bromo-4-methoxyphenethylcarbamate

Guidance literature:: Multi-step reaction with 7 steps

1.1: triethylamine / dichloromethane / 0.75 h / 0 - 20 °C

2.1: palladium 10% on activated carbon; hydrogen / ethyl acetate; ethanol / 3 h / 20 °C / 51683.5 Torr

3.1: N-Bromosuccinimide / N,N-dimethyl-formamide / 0.5 h / 0 - 20 °C

4.1: sulfuric acid / water; acetonitrile / 0.17 h / 0 °C

4.2: 1.5 h / 0 - 5 °C

4.3: 0.25 h / 0 °C

5.1: potassium hydroxide / methanol; dichloromethane / 1 h / 20 °C / Inert atmosphere

6.1: potassium carbonate / acetone / 16 h / Reflux

7.1: isopropylmagnesium chloride / toluene; diethyl ether / 1 h / -40 °C

7.2: 0.25 h / -40 °C

7.3: 0.58 h / -40 - 0 °C

With N-Bromosuccinimide; sulfuric acid; palladium 10% on activated carbon; hydrogen; isopropylmagnesium chloride; potassium carbonate; triethylamine; potassium hydroxide; In methanol; diethyl ether; ethanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; acetone; toluene; acetonitrile;
DOI:10.1021/ol400597f