5-bromo-3',5 '-diacetyl-N₄-(2-hydroxyphenyl)-2'-fluoro-2'-deoxycytidine

Base Information

Chemical Name:5-bromo-3',5 '-diacetyl-N₄-(2-hydroxyphenyl)-2'-fluoro-2'-deoxycytidine
CAS No.:1188522-96-4
Molecular Formula:C₁₉H₁₉BrFN₃O₇
Molecular Weight:500.278
Hs Code.:

5-bromo-3',5 '-diacetyl-N<sub>4</sub>-(2-hydroxyphenyl)-2'-fluoro-2'-deoxycytidine

Synonyms:5-bromo-3',5 '-diacetyl-N₄-(2-hydroxyphenyl)-2'-fluoro-2'-deoxycytidine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5-bromo-3',5 '-diacetyl-N₄-(2-hydroxyphenyl)-2'-fluoro-2'-deoxycytidine

Chemical Property:

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Technology Process of 5-bromo-3',5 '-diacetyl-N₄-(2-hydroxyphenyl)-2'-fluoro-2'-deoxycytidine

There total 4 articles about 5-bromo-3',5 '-diacetyl-N₄-(2-hydroxyphenyl)-2'-fluoro-2'-deoxycytidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.6%

: 1188522-93-1
C₁₅H₁₅BrFN₅O₆

: 95-55-6
2-amino-phenol

: 1188522-96-4
5-bromo-3',5 '-diacetyl-N₄-(2-hydroxyphenyl)-2'-fluoro-2'-deoxycytidine

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃;

Reference yield:

: 1188522-91-9
5-bromo-3',5'-diacetyl-2'-fluoro-2'-deoxyuridine

: 1188522-96-4
5-bromo-3',5 '-diacetyl-N₄-(2-hydroxyphenyl)-2'-fluoro-2'-deoxycytidine

Guidance literature:: Multi-step reaction with 2 steps

1: 1,2,3-triazole; triethylamine; trichlorophosphate / acetonitrile / 3.33 h / 0 - 20 °C

2: triethylamine / dichloromethane / 20 °C

With 1,2,3-triazole; triethylamine; trichlorophosphate; In dichloromethane; acetonitrile;

Reference yield:

: 10212-13-2
3’,5’-O-acetyl-2’-deoxy-2’-fluorouridine

: 1188522-96-4
5-bromo-3',5 '-diacetyl-N₄-(2-hydroxyphenyl)-2'-fluoro-2'-deoxycytidine

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine / 18 h / 20 °C

2: 1,2,3-triazole; triethylamine; trichlorophosphate / acetonitrile / 3.33 h / 0 - 20 °C

3: triethylamine / dichloromethane / 20 °C

With 1,2,3-triazole; triethylamine; trichlorophosphate; In pyridine; dichloromethane; acetonitrile;