2,6-bis(4-methoxyphenyl)-1-methylpiperidin-4-one O-4-chlorobenzoyloxime

Base Information

Chemical Name:2,6-bis(4-methoxyphenyl)-1-methylpiperidin-4-one O-4-chlorobenzoyloxime
CAS No.:1461755-55-4
Molecular Formula:C₂₇H₂₇ClN₂O₄
Molecular Weight:478.975
Hs Code.:

Synonyms:2,6-bis(4-methoxyphenyl)-1-methylpiperidin-4-one O-4-chlorobenzoyloxime

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Chemical Property of 2,6-bis(4-methoxyphenyl)-1-methylpiperidin-4-one O-4-chlorobenzoyloxime

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Technology Process of 2,6-bis(4-methoxyphenyl)-1-methylpiperidin-4-one O-4-chlorobenzoyloxime

There total 4 articles about 2,6-bis(4-methoxyphenyl)-1-methylpiperidin-4-one O-4-chlorobenzoyloxime which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.25%

: 1461755-51-0
2,6-bis(4-methoxyphenyl)-1-methylpiperidin-4-one oxime

: 122-01-0
4-chloro-benzoyl chloride

: 1461755-55-4
2,6-bis(4-methoxyphenyl)-1-methylpiperidin-4-one O-4-chlorobenzoyloxime

Guidance literature:: 2,6-bis(4-methoxyphenyl)-1-methylpiperidin-4-one oxime; With potassium tert-butylate; In N,N-dimethyl-formamide; at 20 ℃; for 0.416667h;

4-chloro-benzoyl chloride; In N,N-dimethyl-formamide; at 20 ℃; for 8h;
DOI:10.1007/s00044-013-0793-z

Reference yield:

: 123-11-5
4-methoxy-benzaldehyde

: 1461755-55-4
2,6-bis(4-methoxyphenyl)-1-methylpiperidin-4-one O-4-chlorobenzoyloxime

Guidance literature:: Multi-step reaction with 4 steps

1.1: ammonium acetate / ethanol / Heating

2.1: potassium carbonate / acetone / 4 h / Reflux

3.1: sodium acetate trihydrate / ethanol / 0.25 h / Heating

3.2: 2 h / Reflux

4.1: potassium tert-butylate / N,N-dimethyl-formamide / 0.42 h / 20 °C

4.2: 8 h / 20 °C

With potassium tert-butylate; ammonium acetate; sodium acetate trihydrate; potassium carbonate; In ethanol; N,N-dimethyl-formamide; acetone; 1.1: |Mannich Aminomethylation;
DOI:10.1007/s00044-013-0793-z

Reference yield:

: 199285-47-7
2,6-bis(4-methoxyphenyl)piperidin-4-one

: 1461755-55-4
2,6-bis(4-methoxyphenyl)-1-methylpiperidin-4-one O-4-chlorobenzoyloxime

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / acetone / 4 h / Reflux

2.1: sodium acetate trihydrate / ethanol / 0.25 h / Heating

2.2: 2 h / Reflux

3.1: potassium tert-butylate / N,N-dimethyl-formamide / 0.42 h / 20 °C

3.2: 8 h / 20 °C

With potassium tert-butylate; sodium acetate trihydrate; potassium carbonate; In ethanol; N,N-dimethyl-formamide; acetone;
DOI:10.1007/s00044-013-0793-z