methyl 2-[5-(dimethoxymethyl)-2,3-dimethoxyphenyl]-3-hydroxy-3-(4-methoxyphenyl)propanoate

Base Information

Chemical Name:methyl 2-[5-(dimethoxymethyl)-2,3-dimethoxyphenyl]-3-hydroxy-3-(4-methoxyphenyl)propanoate
CAS No.:578020-90-3
Molecular Formula:C₂₂H₂₈O₈
Molecular Weight:420.46
Hs Code.:

Synonyms:methyl 2-[5-(dimethoxymethyl)-2,3-dimethoxyphenyl]-3-hydroxy-3-(4-methoxyphenyl)propanoate

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Chemical Property of methyl 2-[5-(dimethoxymethyl)-2,3-dimethoxyphenyl]-3-hydroxy-3-(4-methoxyphenyl)propanoate

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Technology Process of methyl 2-[5-(dimethoxymethyl)-2,3-dimethoxyphenyl]-3-hydroxy-3-(4-methoxyphenyl)propanoate

There total 14 articles about methyl 2-[5-(dimethoxymethyl)-2,3-dimethoxyphenyl]-3-hydroxy-3-(4-methoxyphenyl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 123-11-5
4-methoxy-benzaldehyde

: 578020-89-0
methyl [5-(dimethoxymethyl)-2,3-dimethoxyphenyl]acetate

: 578020-90-3
methyl 2-[5-(dimethoxymethyl)-2,3-dimethoxyphenyl]-3-hydroxy-3-(4-methoxyphenyl)propanoate

Guidance literature:: With lithium diisopropyl amide; In diethyl ether; at -78 ℃; for 1h;
DOI:10.1002/hlca.200390036

Reference yield:

: 5653-67-8
2,3-dimethoxybenzyl alcohol

: 578020-90-3
methyl 2-[5-(dimethoxymethyl)-2,3-dimethoxyphenyl]-3-hydroxy-3-(4-methoxyphenyl)propanoate

Guidance literature:: Multi-step reaction with 7 steps

1: 95 percent / SOCl₂; pyridine / CHCl₃ / 0.75 h / 20 °C

2: 99 percent / ethanol; H₂O / 1 h / Heating

3: 90 percent / NaOH / H₂O; ethanol / 10 h / Heating

4: 97 percent / SOCl₂ / 1.5 h / 0 °C

5: 7.5 percent / SnCl₄ / CH₂Cl₂ / 2 h / 0 - 20 °C

6: 75 percent / NH₄Cl / methanol / 2 h / Heating

7: 73 percent / LDA / diethyl ether / 1 h / -78 °C

With pyridine; sodium hydroxide; thionyl chloride; tin(IV) chloride; ammonium chloride; lithium diisopropyl amide; In methanol; diethyl ether; ethanol; dichloromethane; chloroform; water; 5: Rieche formylation;
DOI:10.1002/hlca.200390036

Reference yield:

: 22280-95-1
4-allyloxy-3-methoxybenzaldehyde

: 578020-90-3
methyl 2-[5-(dimethoxymethyl)-2,3-dimethoxyphenyl]-3-hydroxy-3-(4-methoxyphenyl)propanoate

Guidance literature:: Multi-step reaction with 7 steps

1: 88 percent / 1,3,5-trimethyl-benzene / 20 h / Heating

2: 92 percent / K₂CO₃ / dimethylformamide / 8 h / 20 °C

3: 95 percent / NH₄Cl / methanol / 2 h / Heating

4: 52 percent / NaIO₄; KMnO₄; K₂CO₃ / H₂O; 2-methyl-propan-2-ol / 4 h / 20 °C

5: 75 percent / SOCl₂ / 1.5 h / 0 °C

6: 75 percent / NH₄Cl / methanol / 2 h / Heating

7: 73 percent / LDA / diethyl ether / 1 h / -78 °C

With potassium permanganate; sodium periodate; thionyl chloride; potassium carbonate; ammonium chloride; lithium diisopropyl amide; In methanol; diethyl ether; water; N,N-dimethyl-formamide; tert-butyl alcohol; 1,3,5-trimethyl-benzene; 1: Claisen rearrangement / 4: Lemieux-van Rudloff oxidation;
DOI:10.1002/hlca.200390036