1-adamantyl 2,2,2-trifluoroethyl ether

Base Information

• Chemical Name: 1-adamantyl 2,2,2-trifluoroethyl ether
• CAS No.: 74975-65-8
• Molecular Formula: C₁₂H₁₇F₃O
• Molecular Weight: 234.262
• Mol file: 74975-65-8.mol

Synonyms:1-adamantyl 2,2,2-trifluoroethyl ether

Chemical Property of 1-adamantyl 2,2,2-trifluoroethyl ether

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-adamantyl 2,2,2-trifluoroethyl ether

There total 7 articles about 1-adamantyl 2,2,2-trifluoroethyl ether which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 16.0%

2,2,2-trifluoroethanol (75-89-8) + N-1-adamantyl-N-p-tolylcarbamoyl chloride (197569-70-3) → 1-chloroadamantane (935-56-8) + 1-adamantyl 2,2,2-trifluoroethyl ether (74975-65-8) + p-Tolylisocyanate (622-58-2,374675-64-6)

Guidance literature:

at 0 - 25 ℃; for 95.5h;

DOI:10.1002/(SICI)1099-1395(199708)10:8<600::AID-POC928>3.0.CO;2-Q

Reference yield:

2,2,2-trifluoroethanol (75-89-8) + 1-adamantyl chloroformate (5854-52-4) → 1-chloroadamantane (935-56-8) + 1-adamanthanol (768-95-6) + 1-adamantyl 2,2,2-trifluoroethyl ether (74975-65-8)

Guidance literature:

In pentane; at 25 ℃; Product distribution; also with aq. TFE;

DOI:10.1021/jo00301a019

Reference yield:

ethanol (64-17-5) + 2,2,2-trifluoroethanol (75-89-8) + 1-adamantyl chloroformate (5854-52-4) → 1-chloroadamantane (935-56-8) + 1-Adamantyl ethyl ether (6221-75-6) + 1-adamanthanol (768-95-6) + 1-adamantyl 2,2,2-trifluoroethyl ether (74975-65-8)

Guidance literature:

In pentane; at 25 ℃; Rate constant; Product distribution; various solvent ratios (TFE/EtOH);

DOI:10.1021/jo00301a019

upstream raw materials:

1-Adamantyl bromide

2,2,2-trifluoroethanol

ethanol

1-adamantyl fluoride

Downstream raw materials:

1-adamanthanol

Refernces

• 1、 Kevill, Dennis N.,Kyong, Jin Burm. "Multiple Pathways in the Solvolysis of 1-Adamantyl Fluoroformate". . p. 258 - 265. Retrieved 2007/10/02.
• 2、 Kaspi, Joseph,Rappoport, Zvi. "Solvolysis in 2,2,2-Trifluoroethanol-Water and 2,2,2-Trifluoroethanol-Etanol Mixtures. Selectivity of the Intermediates and N Values". . p. 3829 - 3837. Retrieved 2007/10/02.