7-(trifluoromethyl)-3-(4-(benzyloxy)phenyl)-1-[4-(4-methoxyphenyl)phenyl]-1,2-dihydrobenzo[1,2,4]triazin-2-yl

Base Information

Chemical Name:7-(trifluoromethyl)-3-(4-(benzyloxy)phenyl)-1-[4-(4-methoxyphenyl)phenyl]-1,2-dihydrobenzo[1,2,4]triazin-2-yl
CAS No.:1621378-20-8
Molecular Formula:C₃₄H₂₅F₃N₃O₂
Molecular Weight:564.587
Hs Code.:

Synonyms:7-(trifluoromethyl)-3-(4-(benzyloxy)phenyl)-1-[4-(4-methoxyphenyl)phenyl]-1,2-dihydrobenzo[1,2,4]triazin-2-yl

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Chemical Property of 7-(trifluoromethyl)-3-(4-(benzyloxy)phenyl)-1-[4-(4-methoxyphenyl)phenyl]-1,2-dihydrobenzo[1,2,4]triazin-2-yl

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Technology Process of 7-(trifluoromethyl)-3-(4-(benzyloxy)phenyl)-1-[4-(4-methoxyphenyl)phenyl]-1,2-dihydrobenzo[1,2,4]triazin-2-yl

There total 14 articles about 7-(trifluoromethyl)-3-(4-(benzyloxy)phenyl)-1-[4-(4-methoxyphenyl)phenyl]-1,2-dihydrobenzo[1,2,4]triazin-2-yl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 7-(trifluoromethyl)-3-(4-(benzyloxy)phenyl)-1-(4-iodophenyl)-1,2-dihydrobenzo[1,2,4]triazin-2-yl

: 5720-07-0
4-methoxyphenylboronic acid

: 1621378-20-8
7-(trifluoromethyl)-3-(4-(benzyloxy)phenyl)-1-[4-(4-methoxyphenyl)phenyl]-1,2-dihydrobenzo[1,2,4]triazin-2-yl

Guidance literature:: With palladium diacetate; potassium carbonate; In water; toluene; for 12h; Inert atmosphere; Reflux;
DOI:10.1021/jo500898e

Reference yield: 51.0%

: 7-(trifluoromethyl)-3-(4-(benzyloxy)phenyl)-1-(4-iodophenyl)-1,2-dihydrobenzo[1,2,4]triazin-2-yl

: potassium 4-(methoxy)phenyltrifluoroborate

: 1621378-20-8
7-(trifluoromethyl)-3-(4-(benzyloxy)phenyl)-1-[4-(4-methoxyphenyl)phenyl]-1,2-dihydrobenzo[1,2,4]triazin-2-yl

: 1621378-21-9
C₂₇H₁₉F₃N₃O

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; caesium carbonate; In water; toluene; for 24h; Inert atmosphere; Reflux;
DOI:10.1021/jo500898e

Reference yield:

: 1486-51-7
p-(benzyloxy)benzoic acid

: 1621378-20-8
7-(trifluoromethyl)-3-(4-(benzyloxy)phenyl)-1-[4-(4-methoxyphenyl)phenyl]-1,2-dihydrobenzo[1,2,4]triazin-2-yl

Guidance literature:: Multi-step reaction with 6 steps

1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 20 °C / Inert atmosphere

2: triethylamine / dichloromethane / 2 h / 20 °C / Inert atmosphere

3: thionyl chloride / Inert atmosphere; Reflux

4: triethylamine / dichloromethane / 20 °C / Inert atmosphere

5: 1,8-diazabicyclo[5.4.0]undec-7-ene; palladium 10% on activated carbon / dichloromethane / 20 °C / Inert atmosphere

6: potassium carbonate; palladium diacetate / water; toluene / 12 h / Inert atmosphere; Reflux

With thionyl chloride; oxalyl dichloride; palladium 10% on activated carbon; palladium diacetate; potassium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; N,N-dimethyl-formamide; In dichloromethane; water; toluene; 6: |Suzuki Coupling;
DOI:10.1021/jo500898e