1-(3,4-dihydroisoquinolin-2(1H)-yl)-3-((2'-phenoxy-[1,1'-biphenyl]-3-yl)oxy)propan-2-ol formate

Base Information

Chemical Name:1-(3,4-dihydroisoquinolin-2(1H)-yl)-3-((2'-phenoxy-[1,1'-biphenyl]-3-yl)oxy)propan-2-ol formate
CAS No.:1616098-97-5
Molecular Formula:CH₂O₂*C₃₀H₂₉NO₃
Molecular Weight:497.591
Hs Code.:

Synonyms:1-(3,4-dihydroisoquinolin-2(1H)-yl)-3-((2'-phenoxy-[1,1'-biphenyl]-3-yl)oxy)propan-2-ol formate

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Chemical Property of 1-(3,4-dihydroisoquinolin-2(1H)-yl)-3-((2'-phenoxy-[1,1'-biphenyl]-3-yl)oxy)propan-2-ol formate

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Technology Process of 1-(3,4-dihydroisoquinolin-2(1H)-yl)-3-((2'-phenoxy-[1,1'-biphenyl]-3-yl)oxy)propan-2-ol formate

There total 5 articles about 1-(3,4-dihydroisoquinolin-2(1H)-yl)-3-((2'-phenoxy-[1,1'-biphenyl]-3-yl)oxy)propan-2-ol formate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 15.0%

: 64-18-6
formic acid

: 7025-06-1
1-bromo-2-phenoxybenzene

: 1616099-47-8
1-(3,4-dihydroisoquinolin-2(1H)-yl)-3-(3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy)propan-2-ol

: 1616098-97-5
1-(3,4-dihydroisoquinolin-2(1H)-yl)-3-((2'-phenoxy-[1,1'-biphenyl]-3-yl)oxy)propan-2-ol formate

Guidance literature:: 1-bromo-2-phenoxybenzene; 1-(3,4-dihydroisoquinolin-2(1H)-yl)-3-(3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy)propan-2-ol; With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate; In 1,4-dioxane; water; at 100 ℃; for 0.25h; Microwave irradiation;

formic acid;

Reference yield:

: 591-20-8
3-Bromophenol

: 1616098-97-5
1-(3,4-dihydroisoquinolin-2(1H)-yl)-3-((2'-phenoxy-[1,1'-biphenyl]-3-yl)oxy)propan-2-ol formate

Guidance literature:: Multi-step reaction with 4 steps

1: sodium hydride / N,N-dimethyl-formamide / 16 h / 9 °C

2: methanol / 16 h / 8 °C / Reflux

3: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate / dimethyl sulfoxide / 4 h / 20 - 100 °C

4: potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 0.25 h / 100 °C / Microwave irradiation

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate; sodium hydride; potassium carbonate; In 1,4-dioxane; methanol; water; dimethyl sulfoxide; N,N-dimethyl-formamide;

Reference yield:

: 5002-98-2
2-((3-bromophenoxy)methyl)oxirane

: 1616098-97-5
1-(3,4-dihydroisoquinolin-2(1H)-yl)-3-((2'-phenoxy-[1,1'-biphenyl]-3-yl)oxy)propan-2-ol formate

Guidance literature:: Multi-step reaction with 3 steps

1: methanol / 16 h / 8 °C / Reflux

2: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate / dimethyl sulfoxide / 4 h / 20 - 100 °C

3: potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 0.25 h / 100 °C / Microwave irradiation

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate; potassium carbonate; In 1,4-dioxane; methanol; water; dimethyl sulfoxide;