Technology Process of ethyl 4-chloro-3-(methylamino)-2-nitrobenzoate
There total 4 articles about ethyl 4-chloro-3-(methylamino)-2-nitrobenzoate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
ethyl 3-amino-4-chloro-2-nitrobenzoate;
With
sodium hydride;
In
N,N-dimethyl-formamide;
for 0.5h;
Inert atmosphere;
methyl iodide;
In
N,N-dimethyl-formamide;
at 20 ℃;
for 2.5h;
Inert atmosphere;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: potassium carbonate / N,N-dimethyl-formamide / 0.5 h / 60 °C
1.2: 7 h / 20 °C
2.1: nitric acid / 2 h / -10 - 0 °C
2.2: 25 h / Reflux
3.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / Inert atmosphere
3.2: 2.5 h / 20 °C / Inert atmosphere
With
nitric acid; sodium hydride; potassium carbonate;
In
N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: sodium hydrogencarbonate / tetrahydrofuran; acetic acid / 15 h / 20 °C / Reflux
2.1: potassium carbonate / N,N-dimethyl-formamide / 0.5 h / 60 °C
2.2: 7 h / 20 °C
3.1: nitric acid / 2 h / -10 - 0 °C
3.2: 25 h / Reflux
4.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / Inert atmosphere
4.2: 2.5 h / 20 °C / Inert atmosphere
With
nitric acid; sodium hydride; sodium hydrogencarbonate; potassium carbonate;
In
tetrahydrofuran; acetic acid; N,N-dimethyl-formamide;
