(S)-2-({(S)-2-[(S)-2-((R)-2-tert-Butoxycarbonylamino-3-tritylsulfanyl-propylamino)-3,3-dimethyl-butyryl]-1,2,3,4-tetrahydro-isoquinoline-3-carbonyl}-amino)-4-dimethylcarbamoyl-butyric acid tert-butyl ester

Base Information

Chemical Name:(S)-2-({(S)-2-[(S)-2-((R)-2-tert-Butoxycarbonylamino-3-tritylsulfanyl-propylamino)-3,3-dimethyl-butyryl]-1,2,3,4-tetrahydro-isoquinoline-3-carbonyl}-amino)-4-dimethylcarbamoyl-butyric acid tert-butyl ester
CAS No.:1054652-15-1
Molecular Formula:C₅₄H₇₁N₅O₇S
Molecular Weight:934.253
Hs Code.:

(S)-2-({(S)-2-[(S)-2-((R)-2-tert-Butoxycarbonylamino-3-tritylsulfanyl-propylamino)-3,3-dimethyl-butyryl]-1,2,3,4-tetrahydro-isoquinoline-3-carbonyl}-amino)-4-dimethylcarbamoyl-butyric acid tert-butyl ester

Synonyms:(S)-2-({(S)-2-[(S)-2-((R)-2-tert-Butoxycarbonylamino-3-tritylsulfanyl-propylamino)-3,3-dimethyl-butyryl]-1,2,3,4-tetrahydro-isoquinoline-3-carbonyl}-amino)-4-dimethylcarbamoyl-butyric acid tert-butyl ester

Suppliers and Price of (S)-2-({(S)-2-[(S)-2-((R)-2-tert-Butoxycarbonylamino-3-tritylsulfanyl-propylamino)-3,3-dimethyl-butyryl]-1,2,3,4-tetrahydro-isoquinoline-3-carbonyl}-amino)-4-dimethylcarbamoyl-butyric acid tert-butyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (S)-2-({(S)-2-[(S)-2-((R)-2-tert-Butoxycarbonylamino-3-tritylsulfanyl-propylamino)-3,3-dimethyl-butyryl]-1,2,3,4-tetrahydro-isoquinoline-3-carbonyl}-amino)-4-dimethylcarbamoyl-butyric acid tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (S)-2-({(S)-2-[(S)-2-((R)-2-tert-Butoxycarbonylamino-3-tritylsulfanyl-propylamino)-3,3-dimethyl-butyryl]-1,2,3,4-tetrahydro-isoquinoline-3-carbonyl}-amino)-4-dimethylcarbamoyl-butyric acid tert-butyl ester

There total 6 articles about (S)-2-({(S)-2-[(S)-2-((R)-2-tert-Butoxycarbonylamino-3-tritylsulfanyl-propylamino)-3,3-dimethyl-butyryl]-1,2,3,4-tetrahydro-isoquinoline-3-carbonyl}-amino)-4-dimethylcarbamoyl-butyric acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 62965-10-0
(S)-N-carbobenzoxy-tert-butylleucine

: 1054652-15-1
(S)-2-({(S)-2-[(S)-2-((R)-2-tert-Butoxycarbonylamino-3-tritylsulfanyl-propylamino)-3,3-dimethyl-butyryl]-1,2,3,4-tetrahydro-isoquinoline-3-carbonyl}-amino)-4-dimethylcarbamoyl-butyric acid tert-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 45 percent / N,N-diisopropylethylamine, Bop-Cl / CH₂Cl₂ / a) from 0 deg C to 5 deg C, 2 h, b) 5 deg C, 16 h

2: 100 percent / 1 N NaOH / methanol / 2 h / Ambient temperature

3: N,N-diisopropylethylamine, Bop / acetonitrile; dimethylformamide / 16 h / Ambient temperature

4: H₂, 1 N HCl / 10percent palladium hydroxide/C / tetrahydrofuran / 3 h

5: acetic acid, sodium cyanoborohydride / methanol / 2.25 h / Ambient temperature

With hydrogenchloride; sodium hydroxide; hydrogen; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; sodium cyanoborohydride; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; acetic acid; N-ethyl-N,N-diisopropylamine; palladium hydroxide - carbon; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm950642a

Reference yield:

: 78183-55-8
(S)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid, methyl ester, hydrochloride

: 1054652-15-1
(S)-2-({(S)-2-[(S)-2-((R)-2-tert-Butoxycarbonylamino-3-tritylsulfanyl-propylamino)-3,3-dimethyl-butyryl]-1,2,3,4-tetrahydro-isoquinoline-3-carbonyl}-amino)-4-dimethylcarbamoyl-butyric acid tert-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 45 percent / N,N-diisopropylethylamine, Bop-Cl / CH₂Cl₂ / a) from 0 deg C to 5 deg C, 2 h, b) 5 deg C, 16 h

2: 100 percent / 1 N NaOH / methanol / 2 h / Ambient temperature

3: N,N-diisopropylethylamine, Bop / acetonitrile; dimethylformamide / 16 h / Ambient temperature

4: H₂, 1 N HCl / 10percent palladium hydroxide/C / tetrahydrofuran / 3 h

5: acetic acid, sodium cyanoborohydride / methanol / 2.25 h / Ambient temperature

With hydrogenchloride; sodium hydroxide; hydrogen; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; sodium cyanoborohydride; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; acetic acid; N-ethyl-N,N-diisopropylamine; palladium hydroxide - carbon; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm950642a

Reference yield:

: 166169-82-0
(S)-1,2,3,4-tetrahydro-2-<3-methyl-N-<(phenylmethoxy)-carbonyl>-L-valyl>-3-isoquinolinecarboxylic acid

: 1054652-15-1
(S)-2-({(S)-2-[(S)-2-((R)-2-tert-Butoxycarbonylamino-3-tritylsulfanyl-propylamino)-3,3-dimethyl-butyryl]-1,2,3,4-tetrahydro-isoquinoline-3-carbonyl}-amino)-4-dimethylcarbamoyl-butyric acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: N,N-diisopropylethylamine, Bop / acetonitrile; dimethylformamide / 16 h / Ambient temperature

2: H₂, 1 N HCl / 10percent palladium hydroxide/C / tetrahydrofuran / 3 h

3: acetic acid, sodium cyanoborohydride / methanol / 2.25 h / Ambient temperature

With hydrogenchloride; hydrogen; sodium cyanoborohydride; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; acetic acid; N-ethyl-N,N-diisopropylamine; palladium hydroxide - carbon; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm950642a