2-[D₂]-4-phenylbutanoic acid

Base Information

Chemical Name:2-[D₂]-4-phenylbutanoic acid
CAS No.:51086-43-2
Molecular Formula:C₁₀H₁₂O₂
Molecular Weight:166.188
Hs Code.:

Synonyms:2-[D₂]-4-phenylbutanoic acid

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Chemical Property of 2-[D₂]-4-phenylbutanoic acid

Chemical Property:

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Technology Process of 2-[D₂]-4-phenylbutanoic acid

There total 7 articles about 2-[D₂]-4-phenylbutanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 17428-98-7
2-[D₂]-3-phenylpropan-1-ol

: 51086-43-2
2-[D₂]-4-phenylbutanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: iodine; triphenylphosphine; 1H-imidazole / dichloromethane / 20 °C

2.1: n-butyllithium / tetrahydrofuran / 2 h / -30 °C

2.2: 0.5 h / -30 °C

3.1: sodium hydrogencarbonate / water; acetonitrile / 24 h / 20 °C

4.1: sodium chlorite; sodium dihydrogen phosphate monohydrate / water; methylbutane; tert-butyl alcohol / 2.25 h

With 1H-imidazole; sodium chlorite; n-butyllithium; sodium dihydrogen phosphate monohydrate; iodine; sodium hydrogencarbonate; triphenylphosphine; In tetrahydrofuran; methylbutane; dichloromethane; water; acetonitrile; tert-butyl alcohol;
DOI:10.1002/anie.201804197

Reference yield:

: 100-39-0
benzyl bromide

: 51086-43-2
2-[D₂]-4-phenylbutanoic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: lithium diisopropyl amide / tetrahydrofuran / 3 h / Reflux

1.2: Reflux

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 4 h / Reflux

3.1: iodine; triphenylphosphine; 1H-imidazole / dichloromethane / 20 °C

4.1: n-butyllithium / tetrahydrofuran / 2 h / -30 °C

4.2: 0.5 h / -30 °C

5.1: sodium hydrogencarbonate / water; acetonitrile / 24 h / 20 °C

6.1: sodium chlorite; sodium dihydrogen phosphate monohydrate / water; methylbutane; tert-butyl alcohol / 2.25 h

With 1H-imidazole; sodium chlorite; lithium aluminium tetrahydride; n-butyllithium; sodium dihydrogen phosphate monohydrate; iodine; sodium hydrogencarbonate; triphenylphosphine; lithium diisopropyl amide; In tetrahydrofuran; methylbutane; dichloromethane; water; acetonitrile; tert-butyl alcohol;
DOI:10.1002/anie.201804197

Reference yield:

: 19136-97-1
α-dideuterated 3-phenyl propionic acid

: 51086-43-2
2-[D₂]-4-phenylbutanoic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 4 h / Reflux

2.1: iodine; triphenylphosphine; 1H-imidazole / dichloromethane / 20 °C

3.1: n-butyllithium / tetrahydrofuran / 2 h / -30 °C

3.2: 0.5 h / -30 °C

4.1: sodium hydrogencarbonate / water; acetonitrile / 24 h / 20 °C

5.1: sodium chlorite; sodium dihydrogen phosphate monohydrate / water; methylbutane; tert-butyl alcohol / 2.25 h

With 1H-imidazole; sodium chlorite; lithium aluminium tetrahydride; n-butyllithium; sodium dihydrogen phosphate monohydrate; iodine; sodium hydrogencarbonate; triphenylphosphine; In tetrahydrofuran; methylbutane; dichloromethane; water; acetonitrile; tert-butyl alcohol;
DOI:10.1002/anie.201804197