(3R,4S)-4-Benzyloxycarbonylamino-8-(2,3-bis-benzyloxy-benzoylamino)-3-hydroxy-octanoic acid ethyl ester

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Chemical Name:(3R,4S)-4-Benzyloxycarbonylamino-8-(2,3-bis-benzyloxy-benzoylamino)-3-hydroxy-octanoic acid ethyl ester
CAS No.:167275-82-3
Molecular Formula:C₃₉H₄₄N₂O₈
Molecular Weight:668.787
Hs Code.:

Synonyms:(3R,4S)-4-Benzyloxycarbonylamino-8-(2,3-bis-benzyloxy-benzoylamino)-3-hydroxy-octanoic acid ethyl ester

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Chemical Property of (3R,4S)-4-Benzyloxycarbonylamino-8-(2,3-bis-benzyloxy-benzoylamino)-3-hydroxy-octanoic acid ethyl ester

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Technology Process of (3R,4S)-4-Benzyloxycarbonylamino-8-(2,3-bis-benzyloxy-benzoylamino)-3-hydroxy-octanoic acid ethyl ester

There total 7 articles about (3R,4S)-4-Benzyloxycarbonylamino-8-(2,3-bis-benzyloxy-benzoylamino)-3-hydroxy-octanoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 167275-72-1
(S)-4-Benzyloxycarbonylamino-8-tert-butoxycarbonylamino-3-oxo-octanoic acid ethyl ester

: 167275-82-3
(3R,4S)-4-Benzyloxycarbonylamino-8-(2,3-bis-benzyloxy-benzoylamino)-3-hydroxy-octanoic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 66 percent / NaBH₄ / ethanol; tetrahydrofuran / 1.5 h / -78 °C

2: aq. HCl / dioxane / 1.) 0 deg C, 1 h, 2.) r.t., 45 min

3: Et₃N, diethyl phosphorocyanidate / dimethylformamide / 1.) 0 deg C, 4 h, 2.) 0 deg C to r.t., 13 h

With hydrogenchloride; sodium tetrahydroborate; diethyl cyanophosphonate; triethylamine; In tetrahydrofuran; 1,4-dioxane; ethanol; N,N-dimethyl-formamide;
DOI:10.1055/s-1998-5937

Reference yield:

: 167275-73-2
(3R,4S)-4-Benzyloxycarbonylamino-8-tert-butoxycarbonylamino-3-hydroxy-octanoic acid ethyl ester

: 167275-82-3
(3R,4S)-4-Benzyloxycarbonylamino-8-(2,3-bis-benzyloxy-benzoylamino)-3-hydroxy-octanoic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: aq. HCl / dioxane / 1.) 0 deg C, 1 h, 2.) r.t., 45 min

2: Et₃N, diethyl phosphorocyanidate / dimethylformamide / 1.) 0 deg C, 4 h, 2.) 0 deg C to r.t., 13 h

With hydrogenchloride; diethyl cyanophosphonate; triethylamine; In 1,4-dioxane; N,N-dimethyl-formamide;
DOI:10.1055/s-1998-5937