Octanoic acid, 8-[[(1,1-dimethylethoxy)carbonyl]amino]-3-oxo-4-[[(phenylmethoxy)carb onyl]amino]-, ethyl ester, (4S)-

Base Information

Chemical Name:Octanoic acid, 8-[[(1,1-dimethylethoxy)carbonyl]amino]-3-oxo-4-[[(phenylmethoxy)carb onyl]amino]-, ethyl ester, (4S)-
CAS No.:167275-72-1
Molecular Formula:C23H34N2O7
Molecular Weight:450.532
Hs Code.:
Mol file:167275-72-1.mol

Synonyms:

Suppliers and Price of Octanoic acid, 8-[[(1,1-dimethylethoxy)carbonyl]amino]-3-oxo-4-[[(phenylmethoxy)carb onyl]amino]-, ethyl ester, (4S)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Total 4 raw suppliers

Chemical Property of Octanoic acid, 8-[[(1,1-dimethylethoxy)carbonyl]amino]-3-oxo-4-[[(phenylmethoxy)carb onyl]amino]-, ethyl ester, (4S)-

Chemical Property:

Purity/Quality:: 99.90% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of Octanoic acid, 8-[[(1,1-dimethylethoxy)carbonyl]amino]-3-oxo-4-[[(phenylmethoxy)carb onyl]amino]-, ethyl ester, (4S)-

There total 3 articles about Octanoic acid, 8-[[(1,1-dimethylethoxy)carbonyl]amino]-3-oxo-4-[[(phenylmethoxy)carb onyl]amino]-, ethyl ester, (4S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2389-60-8
Z-Lys(Boc)-OH

: 167275-72-1
(S)-4-Benzyloxycarbonylamino-8-tert-butoxycarbonylamino-3-oxo-octanoic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: tetrahydrofuran / 1.) 0 deg C, 1 h, 2.) r.t., 3 h

2: 1.) i-PrMgCl / 1.) THF, -18 deg C, 45 min; r.t., 2.5 h, 2.) -18 deg C, 1 h; r.t., 4.5 h

With isopropylmagnesium chloride; In tetrahydrofuran;
DOI:10.1055/s-1998-5937

Reference yield:

: 141-78-6
ethyl acetate

: Z-Lys(Boc)-NCA

: 167275-72-1
(S)-4-Benzyloxycarbonylamino-8-tert-butoxycarbonylamino-3-oxo-octanoic acid ethyl ester

Guidance literature:: With lithium diisopropyl amide; Yield given. Multistep reaction; 1.) THF, heptane, Et-Ph, -78 deg C, 1 h, 2.) THF, heptane, Et-Ph, 10 min, -78 deg C;
DOI:10.1016/0040-4039(96)01973-9

Reference yield:

: 1071-46-1
hydrogen ethyl malonate

: 141925-85-1
((S)-5-Benzyloxycarbonylamino-6-imidazol-1-yl-6-oxo-hexyl)-carbamic acid tert-butyl ester

: 167275-72-1
(S)-4-Benzyloxycarbonylamino-8-tert-butoxycarbonylamino-3-oxo-octanoic acid ethyl ester

Guidance literature:: With isopropylmagnesium chloride; Yield given. Multistep reaction; 1.) THF, -18 deg C, 45 min; r.t., 2.5 h, 2.) -18 deg C, 1 h; r.t., 4.5 h;
DOI:10.1055/s-1998-5937