5-chloro-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-3-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-2-methylbenzamide

Base Information

Chemical Name:5-chloro-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-3-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-2-methylbenzamide
CAS No.:1403590-88-4
Molecular Formula:C₂₃H₃₀ClN₃O₃
Molecular Weight:431.963
Hs Code.:

Synonyms:5-chloro-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-3-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-2-methylbenzamide

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Chemical Property of 5-chloro-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-3-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-2-methylbenzamide

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Technology Process of 5-chloro-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-3-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-2-methylbenzamide

There total 10 articles about 5-chloro-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-3-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-2-methylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 771579-27-2
3-(aminomethyl)-4,6-dimethyl-1,2-dihydropyridin-2-one

: 1403595-91-4
C₁₅H₂₀ClNO₃

: 1403590-88-4
5-chloro-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-3-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-2-methylbenzamide

Guidance literature:: 3-(aminomethyl)-4,6-dimethyl-1,2-dihydropyridin-2-one; C₁₅H₂₀ClNO₃; In dimethyl sulfoxide; at 20 ℃; for 0.25h;

With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; In dimethyl sulfoxide;

Reference yield:

: 771579-27-2
3-(aminomethyl)-4,6-dimethylpyridin-2-ol

: 1403595-91-4
C₁₅H₂₀ClNO₃

: 1403590-88-4
5-chloro-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-3-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-2-methylbenzamide

Guidance literature:: With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; In dimethyl sulfoxide; at 20 ℃;
DOI:10.1021/acs.jmedchem.5b01501

Reference yield:

: 7499-06-1
5-chloro-2-methylbenzoic acid

: 1403590-88-4
5-chloro-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-3-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-2-methylbenzamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: sulfuric acid / 0.17 h / -10 °C

1.2: 0.5 h / -10 °C

2.1: sodium carbonate / N,N-dimethyl-formamide / 4 h / 60 °C

3.1: water; ammonium chloride; iron / ethanol / 1 h / 80 °C

4.1: acetic acid / methanol / 3 h / 20 °C

5.1: caesium carbonate / acetonitrile / 18 h / 80 °C

6.1: sodium hydroxide; water / ethanol / 1 h / 60 °C

6.2: pH 4 - 6

7.1: dimethyl sulfoxide / 0.25 h / 20 °C

With sulfuric acid; water; iron; sodium carbonate; ammonium chloride; caesium carbonate; acetic acid; sodium hydroxide; In methanol; ethanol; dimethyl sulfoxide; N,N-dimethyl-formamide; acetonitrile;