Technology Process of C21H18O4
There total 6 articles about C21H18O4 which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
Chiralpak AS-H;
In
ethanol; isopropyl alcohol;
Resolution of racemate;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: magnesium / tetrahydrofuran; ethylene dibromide / 0.75 h / 35 °C
2.1: hydrogen / palladium/alumina / tetrahydrofuran
3.1: water; potassium fluoride / tetrahydrofuran / Reflux
4.1: boron tribromide / chloroform / Reflux
4.2: pH >= 12
4.3: pH 5.5 - 6.5
5.1: Chiralpak AS-H / isopropyl alcohol; ethanol / Resolution of racemate
With
potassium fluoride; water; hydrogen; boron tribromide; magnesium;
palladium/alumina;
In
tetrahydrofuran; ethanol; chloroform; ethylene dibromide; isopropyl alcohol;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: 1H-imidazole / N,N-dimethyl-formamide
2.1: magnesium / tetrahydrofuran; ethylene dibromide / 0.75 h / 35 °C
3.1: hydrogen / palladium/alumina / tetrahydrofuran
4.1: water; potassium fluoride / tetrahydrofuran / Reflux
5.1: boron tribromide / chloroform / Reflux
5.2: pH >= 12
5.3: pH 5.5 - 6.5
6.1: Chiralpak AS-H / isopropyl alcohol; ethanol / Resolution of racemate
With
1H-imidazole; potassium fluoride; water; hydrogen; boron tribromide; magnesium;
palladium/alumina;
In
tetrahydrofuran; ethanol; chloroform; ethylene dibromide; N,N-dimethyl-formamide; isopropyl alcohol;