1-(2-{2-methyl-4-[4-((S)-2-methyl-pyrrolidin-1-yl)-piperidin-1-yl]-phenylamino}-ethyl)-cyclohexanecarboxylic acid methyl ester

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Chemical Name:1-(2-{2-methyl-4-[4-((S)-2-methyl-pyrrolidin-1-yl)-piperidin-1-yl]-phenylamino}-ethyl)-cyclohexanecarboxylic acid methyl ester
CAS No.:1350375-51-7
Molecular Formula:C₂₇H₄₃N₃O₂
Molecular Weight:441.657
Hs Code.:

Synonyms:1-(2-{2-methyl-4-[4-((S)-2-methyl-pyrrolidin-1-yl)-piperidin-1-yl]-phenylamino}-ethyl)-cyclohexanecarboxylic acid methyl ester

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Chemical Property of 1-(2-{2-methyl-4-[4-((S)-2-methyl-pyrrolidin-1-yl)-piperidin-1-yl]-phenylamino}-ethyl)-cyclohexanecarboxylic acid methyl ester

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Technology Process of 1-(2-{2-methyl-4-[4-((S)-2-methyl-pyrrolidin-1-yl)-piperidin-1-yl]-phenylamino}-ethyl)-cyclohexanecarboxylic acid methyl ester

There total 6 articles about 1-(2-{2-methyl-4-[4-((S)-2-methyl-pyrrolidin-1-yl)-piperidin-1-yl]-phenylamino}-ethyl)-cyclohexanecarboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 109384-19-2
t-butyl 4-hydroxy piperidine-1-carboxylate

: 1350375-51-7
1-(2-{2-methyl-4-[4-((S)-2-methyl-pyrrolidin-1-yl)-piperidin-1-yl]-phenylamino}-ethyl)-cyclohexanecarboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: dmap; triethylamine / dichloromethane; N,N-dimethyl-formamide / 72 h / 0 - 20 °C

2.1: potassium carbonate / acetonitrile / 40 h / 80 °C

3.1: hydrogenchloride / 1,4-dioxane / 20 h / 0 - 20 °C

4.1: potassium carbonate / dimethyl sulfoxide / 8 h / 90 °C

5.1: hydrogen / palladium 10% on activated carbon / ethanol / 18 h

6.1: sodium tris(acetoxy)borohydride / acetic acid / 1,2-dichloro-ethane / 18 h / 20 °C

6.2: pH 10

With hydrogenchloride; dmap; hydrogen; sodium tris(acetoxy)borohydride; potassium carbonate; triethylamine; palladium 10% on activated carbon; acetic acid; In 1,4-dioxane; ethanol; dichloromethane; dimethyl sulfoxide; 1,2-dichloro-ethane; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 4630-82-4
methyl cyclohexylcarboxylate

: 1350375-51-7
1-(2-{2-methyl-4-[4-((S)-2-methyl-pyrrolidin-1-yl)-piperidin-1-yl]-phenylamino}-ethyl)-cyclohexanecarboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: diisopropylamine; n-butyllithium / tetrahydrofuran; hexanes / 0.5 h / -70 °C

1.2: 1.5 h / -70 - 20 °C

2.1: osmium(VIII) oxide; sodium periodate; water / isopropyl alcohol / 24 h

3.1: sodium tris(acetoxy)borohydride / acetic acid / 1,2-dichloro-ethane / 18 h / 20 °C

3.2: pH 10

With sodium periodate; osmium(VIII) oxide; n-butyllithium; water; sodium tris(acetoxy)borohydride; diisopropylamine; acetic acid; In tetrahydrofuran; hexanes; 1,2-dichloro-ethane; isopropyl alcohol;

Reference yield:

: 67838-02-2
methyl 1-allylcyclohexane-1-carboxylate

: 1350375-51-7
1-(2-{2-methyl-4-[4-((S)-2-methyl-pyrrolidin-1-yl)-piperidin-1-yl]-phenylamino}-ethyl)-cyclohexanecarboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: osmium(VIII) oxide; sodium periodate; water / isopropyl alcohol / 24 h

2.1: sodium tris(acetoxy)borohydride / acetic acid / 1,2-dichloro-ethane / 18 h / 20 °C

2.2: pH 10

With sodium periodate; osmium(VIII) oxide; water; sodium tris(acetoxy)borohydride; acetic acid; In 1,2-dichloro-ethane; isopropyl alcohol;